Evidence map›Paper›PMID 36088503›Full record

ArticleOncogene2022

Transgenic construction and functional miRNA analysis identify the role of miR-7 in prostate cancer suppression.

Can Wang, Wenchao Li, Qiang Hu, Ninghan Feng, Chunhui Liu, Naipeng Shi, Shuqiu Chen, Ming Chen, Han Guan, Zonghao You and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Oncogene, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Can Wang *Department of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, 210009, China.
Wenchao Li *Department of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, 210009, China.
Qiang Hu *Department of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, 210009, China.
Ninghan Feng *Department of Urology, Wuxi No.2 hospital, Nanjing Medical University, Wuxi, 214002, China.ORCID 0000-0002-0892-6102
Chunhui LiuDepartment of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, 210009, China.
Naipeng ShiDepartment of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, 210009, China.
Shuqiu ChenDepartment of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, 210009, China.
Ming ChenDepartment of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, 210009, China. mingchen0712@seu.edu.cn.ORCID 0000-0002-1005-1456
Han GuanDepartment of Urology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, 233004, China. gh668689@126.com.ORCID 0000-0002-7043-6307
Zonghao YouDepartment of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, 210009, China. 101012899@seu.edu.cn.ORCID 0000-0003-4807-9750
Bin XuDepartment of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, 210009, China. njxbseu@seu.edu.cn.ORCID 0000-0002-3507-8073
Zhongda Hospital Southeast University · CNSoutheast University · BDBengbu Medical College · CNWuxi No.2 People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although miR-7 suppresses the initiation and progression in cancers, little is known about its role in prostate cancer, especially in transgenic mouse models. In present study, we found that expression of miR-7, regulated by p53, was lower in prostate cancer tissues, and miR-7 overexpression significantly mitigated prostate cancer cells growth both in vitro, in organoids and in vivo regardless of p53 status. After we generated miR-7 overexpression transgenic mice and miR-7

Indexed as

MicroRNAsProstatic NeoplasmsAnimalsCell Line, TumorCell ProliferationGene Expression Regulation, NeoplasticHumansMaleMiceProgrammed Cell Death 1 ReceptorTumor MicroenvironmentTumor Suppressor Protein p53MicroRNAsMIRN7-1 microRNA, humanProgrammed Cell Death 1 ReceptorTumor Suppressor Protein p53

Identifiers

PMID36088503
OpenAlexW4295872867

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.