ArticlePituitary2022
High prevalence of overweight/obesity and dyslipidemia in patients with intracranial germ cell tumors.
Article in Pituitary, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 5 citations in OpenAlex.
- Intracranial germ cell tumors: an underrecognized diagnostic consideration in adults with sellar/suprasellar lesions.Journal of neuro-oncology · 2026Article
- Beyond the tumor: endocrine and metabolic dysregulation in intracranial germ cell tumors - a retrospective cohort study.Arquivos de neuro-psiquiatria · 2025Article
- High-coverage targeted lipidomics revealed a novel serum lipid dysregulation profile in adult growth hormone deficiency.Endocrine connections · 2025Article
- Clinical characteristics and management of adipsic arginine vasopressin deficiency in children and adolescents with sellar germ cell tumors.European journal of pediatrics · 2024Article
- Dyslipidemia: prevalence and association with precancerous and cancerous lesions of the cervix; a pilot study.Lipids in health and disease · 2024Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
purposeTo evaluate the prevalence of overweight/obesity and dyslipidemia in patients with intracranial germ cell tumor (iGCT), and to explore the risk factors of it.
methodsiGCT patients visiting Peking Union Medical College Hospital between Jan 2008 to Oct 2020 were included. The prevalence of overweight/obesity and dyslipidemia was calculated. Mixed-effects models were used to evaluate the relationship between BMI z-scores, concentration of lipid profiles and potential risk factors.
resultsOne hundred and six patients were included. The median follow-up time was 27 (IQR 5-59) months. The number of patients diagnosed with overweight/obesity and dyslipidemia were 49 (46.2%) and 86 (81.1%) during visits. Higher BMI z-scores were associated with treatment (mean difference (MD) 0.51, 95%CI 0.31-0.72), surgical biopsies (MD 0.71, 95%CI 0.16-1.25), adrenal insufficiency (MD 0.37, 95%CI 0.07-0.68), hypothyroidism (MD 0.35, 95%CI 0.06-0.63), glucocorticoid supplementation (MD 0.64, 95%CI 0.40-0.87), and thyroxine supplementation (MD 0.48, 95%CI 0.24-0.72). Hypothalamus involvement was associated with increased TC (MD 0.52, 95%CI 0.06-0.98), TG (MD 0.36, 95%CI 0.01-0.72), LDL-C (MD 0.60, 95%CI 0.20-0.98), and decreased HDL-C (MD - 0.23, 95%CI - 0.44 to - 0.02). Higher TC (MD 0.53, 95%CI 0.26-0.80) and LDL-C (MD 0.39, 95%CI 0.17-0.62) were observed in patients after treatment. Glucocorticoid supplementation was associated with increased TC (MD 0.70, 95%CI 0.38-1.03), LDL-C (MD 0.51, 95%CI 0.24-0.78), and HDL-C (MD 0.25, 95%CI 0.09-0.40), while sex hormone supplementation was associated with decreased TC (MD - 0.74, 95%CI - 1.2 to - 0.29) and TG (MD - 0.47, 95%CI - 0.86 to - 0.08).
conclusionOverweight/obesity and dyslipidemia were high prevalent in iGCT patients and should be screened during follow-ups.
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