ArticleThe journal of headache and pain2022
Functional connectivity and structural changes of thalamic subregions in episodic migraine.
Article in The journal of headache and pain, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Post-COVID-19 conditions: a systematic review on advanced magnetic resonance neuroimaging findings.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Pooled it
- High-definition tDCS over primary motor cortex modulates brain signal variability and functional connectivity in episodic migraine.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024Trial
- Quantitative pupillometry as a marker of autonomic dysregulation in vestibular migraine.Journal of oral & facial pain and headache · 2026Article
- Abnormal structural connectivity-functional connectivity coupling beyond the cortex in patients with chronic migraine.The journal of headache and pain · 2026Article
- Subcortical nuclei and glymphatic system alterations in migraine with aura: a comparative 7T multimodal MRI analysis.The journal of headache and pain · 2025Article
- Diffusion Tensor Imaging-Based Glymphatic Dysfunction Assessments in Migraine Syndromes: Mechanisms and Diagnostic Implications.Biomedicines · 2025Review
- 3T MRI thalamic segmentation reveals no macrostructural changes in interictal episodic migraine without aura compared to healthy controls.The journal of headache and pain · 2025Article
- Major depressive disorder in fibromyalgia: novel insights from resting-state functional connectivity analysis.The Korean journal of pain · 2025Article
- Functional and Structural Differences of Brain in Patients With Vestibular Migraine: A Resting-State Functional MRI and DTI Study.Brain and behavior · 2025Article
- Association between white matter microstructural and functional abnormalities and clinical characteristics in migraine without aura: a mediation analysis.Frontiers in neurology · 2025Article
- Revolutionizing treatment for disorders of consciousness: a multidisciplinary review of advancements in deep brain stimulation.Military Medical Research · 2024Review
- Discriminative functional connectivity signature of cocaine use disorder links to rTMS treatment response.Nature. Mental health · 2024Article
- Structural and functional changes of anterior cingulate cortex subregions in migraine without aura: relationships with pain sensation and pain emotion.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Genetic mechanisms underlying local spontaneous brain activity in episodic migraine.Frontiers in neuroscience · 2024Article
- Acupuncture-Related Therapy for Knee Osteoarthritis: A Narrative Review of Neuroimaging Studies.Journal of pain research · 2024Review
- Characteristic oscillatory brain networks for predicting patients with chronic migraine.The journal of headache and pain · 2023Article
- A generalizable functional connectivity signature characterizes brain dysfunction and links to rTMS treatment response in cocaine use disorder.medRxiv : the preprint server for health sciences · 2023Article
- The volume of the thalamus and hippocampus in a right-handed female episodic migraine group.Frontiers in neurology · 2023Article
- Functional MRI and Diffusion Tensor Imaging in Migraine: A Review of Migraine Functional and White Matter Microstructural Changes.Journal of central nervous system disease · 2023Review
- The brain structure and function abnormalities of migraineurs: A systematic review and neuroimaging meta-analysis.Frontiers in neurology · 2022Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe thalamus plays a crucial role in transmitting nociceptive information to various cortical regions involving migraine-related allodynia and photophobia. Abnormal structural and functional alterations related to the thalamus have been well established. However, it is unknown whether the brain structure and function of the thalamic subregions are differentially affected in this disorder. In this study, we aimed to clarify this issue by comparing the structure and function of 16 thalamic subregions between patients with episodic migraine (EM) and healthy controls (HCs).
methodsTwenty-seven patients with EM and 30 sex-, age- and education-matched HCs underwent resting-state functional and structural magnetic resonance imaging scans. Functional connectivity (rsFC), grey matter volume (GMV), and diffusion tensor imaging (DTI) parameters of each subregion of the thalamus were calculated and compared between the two groups. Furthermore, correlation analyses between neuroimaging changes and clinical features were performed in this study.
resultsFirst, compared with HCs, patients with EM exhibited decreased rsFC between the anterior-medial-posterior subregions of the thalamus and brain regions mainly involved in the medial system of the pain processing pathway and default mode network (DMN). Second, for the whole thalamus and each of its subregions, there were no significant differences in GMV between patients with EM and HCs (P > 0.05, Bonferroni corrected). Third, there was no significant difference in DTI parameters between the two groups (P > 0.05). Finally, decreased rsFC was closely related to scores on the Hamilton Rating Scale for Anxiety (HAMA) and Big Five Inventory (BFI) scales.
conclusionSelective functional hypoconnectivity in the thalamic subregions provides neuroimaging evidence supporting the important role of thalamocortical pathway dysfunction in episodic migraine, specifically, that it may modulate emotion and different personality traits in migraine patients.
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