ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2022
Source localization of ictal SEEG to predict postoperative seizure outcome.
Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Influences of electrode density on intracranial seizure localisation: a single-blinded randomised crossover study.EBioMedicine · 2025Trial
- How to Recognize and Manage Missing Key Electrodes in Defining the Epileptogenic Zone.Epilepsy currents · 2026Article
- The use of quantitative electroencephalography in evaluating epilepsy treatment.Acta epileptologica · 2026Review
- Modern Aspects of Invasive Epilepsy Monitoring: Utility for Seizure Localization and Therapeutic Decision-Making.Pediatric neurosurgery · 2026Review
- Time-Frequency Fingerprint Analysis in SEEG Source-Space to Identify the Epileptogenic Zone.Annals of clinical and translational neurology · 2025Article
- Stereo-EEG propagating source reconstruction identifies new surgical targets for epilepsy patients.Brain : a journal of neurology · 2025Article
- A spatial perturbation framework to validate implantation of the epileptogenic zone.Nature communications · 2024Article
- Combining independent component analysis and source localization for improving spatial sampling of stereoelectroencephalography in epilepsy.Scientific reports · 2024Article
- Identifying sources of human interictal discharges with travelling wave and white matter propagation.Brain : a journal of neurology · 2023Article
- Seizure detection with reduced electroencephalogram channels: research trends and outlook.Royal Society open science · 2023Review
- Optimization of patient-specific stereo-EEG recording sensitivity.Brain communications · 2023Article
- Ictal source localization from intracranial recordings.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2022Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveStereo-electroencephalography (SEEG) is inherently-three-dimensional and can be modeled using source localization. This study aimed to assess the validity of ictal SEEG source localization.
methodsThe dominant frequency at ictal onset was used for source localization in the time and frequency domains using rotating dipoles and current density maps. Validity was assessed by concordance with the epileptologist-defined seizure onset zone (conventional SOZ) and the surgical treatment volume (TV) of seizure-free versus non-seizure-free patients.
resultsSource localization was performed on 68 seizures from 27 patients. Median distance to nearest contact in the conventional SOZ was 7 (IQR 6-12) mm for time-domain dipoles. Current density predicted ictal activity with up to 86 % (60-87 %) accuracy. Distance from time-domain dipoles to the TV was smaller (P = 0.045) in seizure-free (2 [0-4] mm) versus non-seizure-free (12 [2-17] mm) patients, and predicted surgical outcome with 91 % sensitivity and 63 % specificity. Removing near-field data from contacts within the TV negated outcome prediction (P = 0.51).
conclusionsSource localization of SEEG accurately mapped ictal onset compared with conventional interpretation. Proximity of dipoles to the TV predicted seizure outcome when near-field recordings were analyzed. SIGNIFICANCE: Ictal SEEG source localization is useful in corroborating the epileptogenic zone, assuming near-field recordings are obtained.
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