ArticleJournal of affective disorders2022
Left ventrolateral prefrontal cortical activity during reward expectancy predicts mania risk up to one year post scan.
Article in Journal of affective disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 8 citations in OpenAlex.
- Associations among mediodorsal thalamic-ventrolateral prefrontal cortical white matter fiber dispersion and OCD-related incompleteness.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Elevated pre-supplementary motor area activity during reward expectancy: An impulsivity-related neural marker of vulnerability to bipolar and externalizing disorders.Molecular psychiatry · 2026Article
- High Beta Power in the Ventrolateral Prefrontal Cortex Indexes Human Approach Behavior: A Case Study.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Neural activity to reward and loss predicting treatment outcomes for adults with generalized anxiety disorder: A randomized clinical trial.Journal of mood and anxiety disorders · 2025Article
- Left Ventrolateral Prefrontal Cortical Activity During Reward Expectancy and Mania Risk.JAMA psychiatry · 2025Article
- Neurobehavioral Reward and Sleep-Circadian Profiles Predict Present and Next-Year Mania/Hypomania Symptoms.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Article
- Building a neurobiological framework to elucidate neural mechanisms, aid early risk detection, and develop new treatments for Bipolar Disorder.Psychiatry research · 2023Review
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
introductionIdentification of neural markers associated with risk for manic symptoms is an important challenge for neuropsychiatric research. Previous work has highlighted the association between predisposition for mania/hypomania and elevated reward sensitivity. Elevated activity in the left ventrolateral prefrontal cortex (L vlPFC) during reward expectancy (RE) is associated with measures predictive of risk for manic/hypomanic symptoms. However, no studies have examined this relationship longitudinally. The goal of this study was to identify a neural marker associated with longitudinal risk for manic/hypomanic symptoms.
methodsWe used a card guessing functional magnetic resonance imaging (fMRI) paradigm to examine RE-related L vlPFC activity. One hundred and three young adults who were either healthy or experiencing psychological distress completed a single baseline fMRI scan and self-report measures of manic/hypomanic symptoms. Self-report measures were repeated up to two follow up visits over one year.
resultsWe identified a significant positive relationship between baseline RE-related L vlPFC activity and MOODS Manic Domain scores up to one-year post scan. This relationship was specific to manic symptoms and was not present for MOODS depression-related domains. LIMITATIONS: This study was not designed to predict conversion to bipolar disorder, but rather the more proximal construct of lifetime risk for mania/hypomania.
conclusionsRE-related L vlPFC activity may serve as an important marker of risk for future manic/hypomanic symptoms and may also be a potential target for intervention.
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