ArticleThe Science of the total environment2022
Urban monitoring of antimicrobial resistance during a COVID-19 surge through wastewater surveillance.
Article in The Science of the total environment, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 47 citations in OpenAlex.
- Building-Scale Wastewater Metagenomics Reveals Temporal Patterns in Resistance and Virulence Genes.Antibiotics (Basel, Switzerland) · 2026Article
- The COVID-19 pandemic influenced the temporal dynamics of antimicrobial resistance markers and bacterial community across urban wastewater treatment plants.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Article
- Wastewater intelligence predicts the emergence of clinically-relevant and drug-resistant Candidozyma auris at healthcare facilities.Nature communications · 2026Article
- Wastewater surveillance reveals patterns of antibiotic resistance across the United States.Nature communications · 2026Article
- Tracking Age-Linked Antibiotic Resistance Patterns through Building-Level Wastewater Analysis.ACS ES&T water · 2025Article
- The surveillance of antimicrobial resistance in wastewater from a one health perspective: A global scoping and temporal review (2014-2024).One health (Amsterdam, Netherlands) · 2025Article
- Relating antimicrobial use to wastewater resistance gene patterns via metagenomic analysis of two neighboring treatment plants circa the COVID-19 pandemic.npj antimicrobials and resistance · 2025Article
- Article
- Versatile wastewater monitoring of pathogens and antimicrobial resistance enabled by metatranscriptomics and long-read metagenomics.Research square · 2025Article
- Early detection of emerging SARS-CoV-2 Variants from wastewater through genome sequencing and machine learning.Nature communications · 2025Article
- CARPDM: cost-effective antibiotic resistome profiling of metagenomic samples using targeted enrichment.Applied and environmental microbiology · 2025Article
- Phenotypic Antibiotic Resistance Patterns ofInternational journal of environmental research and public health · 2025Article
- Targeted Enrichment Sequencing Utilizing a Respiratory Pathogen Panel for Genomic Wastewater-Based Viral Epidemiology in Uruguay.Food and environmental virology · 2025Article
- Comparative analysis of qPCR and metagenomics for detecting antimicrobial resistance in wastewater: a case study.BMC research notes · 2025Article
- Biofilms as potential reservoirs of antimicrobial resistance in vulnerable settings.Frontiers in public health · 2025Article
- Wastewater surveillance for antibiotic resistance genes during the late 2020 SARS-CoV-2 peak in two different populations.Journal of water and health · 2024Article
- Environmental Surveillance of Flood Control Infrastructure Impacted by Unsheltered Individuals Leads to the Detection of SARS-CoV-2 and Novel Mutations in the Spike Gene.Environmental science & technology letters · 2024Article
- Wastewater surveillance for bacterial targets: current challenges and future goals.Applied and environmental microbiology · 2024Review
- Wastewater sequencing reveals community and variant dynamics of the collective human virome.Nature communications · 2023Article
- Wastewater surveillance for public health.Science (New York, N.Y.) · 2023Article
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
During the early phase of the COVID-19 pandemic, infected patients presented with symptoms similar to bacterial pneumonias and were treated with antibiotics before confirmation of a bacterial or fungal co-infection. We reasoned that wastewater surveillance could reveal potential relationships between reduced antimicrobial stewardship, specifically misprescribing antibiotics to treat viral infections, and the occurrence of antimicrobial resistance (AMR) in an urban community. Here, we analyzed microbial communities and AMR profiles in sewage samples from a wastewater treatment plant (WWTP) and a community shelter in Las Vegas, Nevada during a COVID-19 surge in December 2020. Using a respiratory pathogen and AMR enrichment next-generation sequencing panel, we identified four major phyla in the wastewater, including Actinobacteria, Firmicutes, Bacteroidetes and Proteobacteria. Consistent with antibiotics that were reportedly used to treat COVID-19 infections (e.g., fluoroquinolones and beta-lactams), we also measured a significant spike in corresponding AMR genes in the wastewater samples. AMR genes associated with colistin resistance (mcr genes) were also identified exclusively at the WWTP, suggesting that multidrug resistant bacterial infections were being treated during this time. We next compared the Las Vegas sewage data to local 2018-2019 antibiograms, which are antimicrobial susceptibility profile reports about common clinical pathogens. Similar to the discovery of higher levels of beta-lactamase resistance genes in sewage during 2020, beta-lactam antibiotics accounted for 51 ± 3 % of reported antibiotics used in antimicrobial susceptibility tests of 2018-2019 clinical isolates. Our data highlight how wastewater-based epidemiology (WBE) can be leveraged to complement more traditional surveillance efforts by providing community-level data to help identify current and emerging AMR threats.
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