ArticleCortex; a journal devoted to the study of the nervous system and behavior2022
Efficient and effective assessment of deficits and their neural bases in stroke aphasia.
Article in Cortex; a journal devoted to the study of the nervous system and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 25 citations in OpenAlex.
- Disentangling phonology from phonological short-term memory in Alzheimer's disease phenotypes.Alzheimer's research & therapy · 2025Article
- Behavioural changes in frontotemporal dementia and their cognitive and neuroanatomical correlates.Brain : a journal of neurology · 2025Article
- The graded multidimensional geometry of phenotypic variation and progression in neurodegenerative syndromes.Brain : a journal of neurology · 2025Article
- Impaired semantic control in the logopenic variant of primary progressive aphasia.Brain communications · 2025Article
- Structural disruption in subjective cognitive decline and mild cognitive impairment.Brain imaging and behavior · 2024Article
- The impact of bilateral versus unilateral anterior temporal lobe damage on face recognition, person knowledge and semantic memory.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Principal component analysis-based latent-space dimensionality under-estimation, with uncorrelated latent variables.Brain : a journal of neurology · 2024Article
- Social-semantic knowledge in frontotemporal dementia and after anterior temporal lobe resection.Brain communications · 2024Article
- Defining aphasia: Content analysis of six aphasia diagnostic batteries.Cortex; a journal devoted to the study of the nervous system and behavior · 2023Article
- Using in vivo functional and structural connectivity to predict chronic stroke aphasia deficits.Brain : a journal of neurology · 2023Article
- Mapping behavioural, cognitive and affective transdiagnostic dimensions in frontotemporal dementia.Brain communications · 2023Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveMulti-assessment batteries are necessary for diagnosing and quantifying the multifaceted deficits observed post-stroke. Extensive batteries are thorough but impractically long for clinical settings or large-scale research studies. Clinically-targeted "shallow" batteries superficially cover a wide range of language skills relatively quickly but can struggle to identify mild deficits or quantify the impairment level. Our aim was to compare these batteries across a large group of chronic stroke aphasia and to test a novel data-driven reduced version of an extensive battery that maintained sensitivity to mild impairment, ability to grade deficits and the underlying component structure.
methodsWe tested 75 chronic left-sided stroke participants, spanning global to mild aphasia. The underlying structure of these three batteries was analysed using cross-validation and principal component analysis, in addition to univariate and multivariate lesion-symptom mapping.
resultsThis revealed a four-factor solution for the extensive and data-reduced batteries, identifying phonology, semantic skills, fluency and executive function in contrast to a two-factor solution using the shallow battery (language severity and cognitive severity). Lesion symptom mapping using participants' factor scores identified convergent neural structures for phonology (superior temporal gyrus), semantics (inferior temporal gyrus), speech fluency (precentral gyrus) and executive function (lateral occipitotemporal cortex). The two shallow battery components converged with the phonology and executive function clusters. In addition, we show that multivariate models could predict the component scores using neural data, however not for every component.
conclusionsOverall, the data-driven battery appears to be an effective way to save time yet retain maintained sensitivity to mild impairment, ability to grade deficits and the underlying component structure observed in post-stroke aphasia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.