ArticleBrain structure & function2022
Central precuneus lesions are associated with impaired executive function.
Article in Brain structure & function, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 45 citations in OpenAlex.
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- Incarcerated adolescents scoring high on the Brown Attention-Deficit Disorder Scale are characterized by impairments within brain regions associated with executive control: A source-based morphometry study.Psychiatry research. Neuroimaging · 2025Article
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- Effects of a healthy diet based on seed-rich vegetables on the gut microbiota and intrinsic brain activity in perimenopausal women: A pilot study on cognitive improvement.Scientific reports · 2025Article
- Altered Brain Functional Connectivity and Topological Structural in Girls with Idiopathic Central Precocious Puberty: A Graph Theory Analysis Based on Resting-State fMRI.Children (Basel, Switzerland) · 2025Article
- Advanced concentrative absorption meditation reorganizes functional connectivity gradients of the brain: 7T MRI and phenomenology case study of jhana meditation.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Development and Training of Mindfulness and Its Relationship with Executive Function in Chinese Rural Upper-Grade Elementary School Students.Behavioral sciences (Basel, Switzerland) · 2025Article
- Intersection of Brain Complexity, Functional Connectivity, and Neuropsychology: A Systematic Review.Cureus · 2025Review
- Trajectories of intrinsic connectivity one year post pediatric mild traumatic brain injury: Neural injury superimposed on neurodevelopment.Cortex; a journal devoted to the study of the nervous system and behavior · 2025Article
- Exploring the links among brain iron accumulation, cognitive performance, and dietary intake in older adults: A longitudinal MRI study.Neurobiology of aging · 2025Article
- Specificity of functional network connectivity during the AD prodromal phase in mild cognitive impairment.Frontiers in psychiatry · 2025Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
The functional roles of the precuneus are unclear. Focal precuneus lesions are rare, making it difficult to identify robust brain-behavior relationships. Distinct functional subdivisions of the precuneus have been proposed based on unique connectivity profiles. This includes an association of the anterior division with bodily awareness, the central region with complex cognition, and the posterior division with visual processing. Our goal was to test the hypothesis that the central precuneus is preferentially involved (compared to the other sectors of the precuneus) in executive function, as estimated from performance on the trail-making test (TMT). 35 patients with focal brain lesions involving the precuneus were included from the University of Iowa and Montpellier University. Multivariate lesion symptom mapping of TMT performance was performed to evaluate whether lesion location was associated with impaired task performance. Lesion symptom mapping revealed a statistically significant association of central precuneus lesions with impaired TMT performance (r = 0.43, p < 0.01). Further, a functional network derived from this precuneus region showed connectivity to other cortical areas implicated in executive function, including the dorsolateral prefrontal cortex and inferior parietal lobe. This analysis provides support for the role of the central precuneus in executive function, consistent with the unique connectivity pattern of the central precuneus with a broader network implicated in cognitive control and executive function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.