Evidence map›Paper›PMID 36086884›Full record

ArticleEuropean journal of immunology2022

Super-killer CTLs are generated by single gene deletion of Bach2.

Philippa R Barton, Alexander J Davenport, Jens Hukelmann, Doreen A Cantrell, Jane C Stinchcombe, Arianne C Richard, Gillian M Griffiths

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Philippa R BartonCambridge Institute for Medical Research, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0XY, UK.
Alexander J DavenportCambridge Institute for Medical Research, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0XY, UK.
Jens HukelmannCell Signalling and Immunology Division, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK.
Doreen A CantrellCell Signalling and Immunology Division, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK.
Jane C StinchcombeCambridge Institute for Medical Research, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0XY, UK.
Arianne C RichardCambridge Institute for Medical Research, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0XY, UK.
Gillian M GriffithsCambridge Institute for Medical Research, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0XY, UK.ORCID 0000-0003-0434-5842
University of Cambridge · GBUniversity of Dundee · GB

Funding

Cancer Research UKMedical Research Council MR/P014178/1Wellcome Trust 205023/Z/16/Z
6 · The paper itself

Abstract

Bach2 codes for a transcriptional regulator exerting major influences on T cell-mediated immune regulation. Effector CTLs derived from in vitro activation of murine CD8

Indexed as

CD8-Positive T-LymphocytesCytotoxicity, ImmunologicAnimalsBasic-Leucine Zipper Transcription FactorsGene DeletionGranzymesMicePerforinProteomicsT-Lymphocytes, CytotoxicBach2 protein, mouseBasic-Leucine Zipper Transcription FactorsGranzymesPerforinBACH2CTLcytotoxicitygranzymesperforin

Identifiers

PMID36086884
PMCPMC9828676
OpenAlexW4295095050

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.