Evidence map›Paper›PMID 36085362›Full record

ArticleHeredity2022

Robust association tests for quantitative traits on the X chromosome.

Zi-Ying Yang, Wei Liu, Yu-Xin Yuan, Yi-Fan Kong, Pei-Zhen Zhao, Wing Kam Fung, Ji-Yuan Zhou

Open access · bronzeAbstract read
In one paragraph

Article in Heredity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Zi-Ying Yang *Department of Biostatistics, State Key Laboratory of Organ Failure Research, Ministry of Education, and Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China.ORCID 0000-0002-5046-0385
Wei Liu *Department of Biostatistics, State Key Laboratory of Organ Failure Research, Ministry of Education, and Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China.ORCID 0000-0002-3140-2120
Yu-Xin Yuan *Department of Biostatistics, State Key Laboratory of Organ Failure Research, Ministry of Education, and Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China.ORCID 0000-0002-5497-7787
Yi-Fan KongDepartment of Biostatistics, State Key Laboratory of Organ Failure Research, Ministry of Education, and Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China.ORCID 0000-0002-5294-8691
Pei-Zhen ZhaoDepartment of Biostatistics, State Key Laboratory of Organ Failure Research, Ministry of Education, and Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China.ORCID 0000-0002-9334-3744
Wing Kam FungDepartment of Statistics and Actuarial Science, The University of Hong Kong, Hong Kong, China. wingfung@hku.hk.ORCID 0000-0002-2508-4015
Ji-Yuan ZhouDepartment of Biostatistics, State Key Laboratory of Organ Failure Research, Ministry of Education, and Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China. zhoujiyuan5460@hotmail.com.ORCID 0000-0003-0866-4402
Southern Medical University · CNGuangdong-Hongkong-Macau Joint Laboratory of Collaborative Innovation for Environmental Quality · CNHong Kong University of Science and Technology · HK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The genome-wide association study is an elementary tool to assess the genetic contribution to complex human traits. However, such association tests are mainly proposed for autosomes, and less attention has been given to methods for identifying loci on the X chromosome due to their distinct biological features. In addition, the existing association tests for quantitative traits on the X chromosome either fail to incorporate the information of males or only detect variance heterogeneity. Therefore, we propose four novel methods, which are denoted as QXcat, QZ

Indexed as

Chromosomes, Human, XGenome-Wide Association StudyFemaleGenotypeHumansMaleModels, GeneticPhenotypePolymorphism, Single NucleotideX Chromosome Inactivation

Identifiers

PMID36085362
PMCPMC9519943
OpenAlexW4298026248

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.