Evidence map›Paper›PMID 36085331›Full record

ArticleNature communications2022

Biofeedback electrostimulation for bionic and long-lasting neural modulation.

Fei Jin, Tong Li, Zhidong Wei, Ruiying Xiong, Lili Qian, Juan Ma, Tao Yuan, Qi Wu, Chengteng Lai, Xiying Ma and 5 more

Abstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Review
  2. Article
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  4. Article
  5. Mechanomedicine.Nature reviews bioengineering · 2026
    Article
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  7. Review
  8. Review
  9. Review
  10. Article
  11. Review
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  15. Review
  16. Article
  17. Review
  18. Article
  19. [Lifetide biofeedback intervention in type 2 diabetic patients: a pilot observation].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Fei Jin *School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing, 210094, P. R. China.ORCID 0000-0002-5670-3915
Tong Li *School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing, 210094, P. R. China.
Zhidong Wei *School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing, 210094, P. R. China.
Ruiying Xiong *School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing, 210094, P. R. China.
Lili QianSchool of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing, 210094, P. R. China.
Juan MaSchool of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing, 210094, P. R. China.
Tao YuanDepartment of Orthopedic, Nanjing Jinling Hospital, Nanjing, 210002, P. R. China.
Qi WuDepartment of Orthopedic, Nanjing Jinling Hospital, Nanjing, 210002, P. R. China.
Chengteng LaiDepartment of Orthopedic, Nanjing Jinling Hospital, Nanjing, 210002, P. R. China.
Xiying MaSchool of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing, 210094, P. R. China.
Fuyi WangSchool of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing, 210094, P. R. China.
Ying ZhaoSchool of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing, 210094, P. R. China.
Fengyu SunSchool of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing, 210094, P. R. China.
Ting WangState Key Laboratory of Bioelectronics, Southeast University, Nanjing, 210096, P. R. China. echo2165@163.com.ORCID 0000-0002-7518-6298
Zhang-Qi FengSchool of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing, 210094, P. R. China. fengzhangqi1981@163.com.ORCID 0000-0002-1684-588X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Invasive electrical stimulation (iES) is prone to cause neural stimulus-inertia owing to its excessive accumulation of exogenous charges, thereby resulting in many side effects and even failure of nerve regeneration and functional recovery. Here, a wearable neural iES system is well designed and built for bionic and long-lasting neural modulation. It can automatically yield biomimetic pulsed electrical signals under the driven of respiratory motion. These electrical signals are full of unique physiological synchronization can give biofeedback to respiratory behaviors, self-adjusting with different physiological states of the living body, and thus realizing a dynamic and biological self-matched modulation of voltage-gated calcium channels on the cell membrane. Abundant cellular and animal experimental evidence confirm an effective elimination of neural stimulus-inertia by these bioelectrical signals. An unprecedented nerve regeneration and motor functional reconstruction are achieved in long-segmental peripheral nerve defects, which is equal to the gold standard of nerve repair -- autograft. The wearable neural iES system provides an advanced platform to overcome the common neural stimulus-inertia and gives a broad avenue for personalized iES therapy of nerve injury and neurodegenerative diseases.

Indexed as

BionicsElectric Stimulation TherapyAnimalsBiofeedback, PsychologyElectric StimulationNerve Regeneration

Identifiers

PMID36085331
PMCPMC9463164

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.