ArticleCommunications biology2022
Human lung-resident mucosal-associated invariant T cells are abundant, express antimicrobial proteins, and are cytokine responsive.
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Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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33citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 7% of its field
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Immune checkpoint expression in mucosal-associated invariant T cells is stimulus-dependent.Journal of leukocyte biology · 2025Pooled it
- Antigenic stimulation in conjunction with cytokine is required for mediating IL-17A production in human MAIT cells.Scientific reports · 2026Article
- Sorting endosomes play key roles in presentation of Mycobacterium tuberculosis-derived ligands to MAIT cells.Scientific reports · 2026Article
- Restoration of Mucosa-Associated Invariant T-Cell Function in Healthcare-Associated Bacterial Infections Supports Recovery of Carbapenem Efficacy Against Resistant Bacteria Ex Vivo.The Journal of infectious diseases · 2026Article
- Signal Transducer and Activator of Transcription (STAT) Proteins Regulate Mucosal-Associated Invariant T (MAIT) Cell Function.Immunology · 2026Article
- Role of Donor Unrestricted T Cells (DURTs) in TB Host Defense: Implications for Novel TB Vaccine Development.Vaccines · 2026Review
- Article
- Innate-like T Cell Biology in the Tumor Microenvironment Implications for Cancer Immunotherapy.Cells · 2026Review
- Dual Roles of MAIT Cells in the Tumor Microenvironment: Implications for Cancer Immunity and Therapy.Immune network · 2026Review
- Antigenic stimulation in conjunction with cytokine is required for mediating IL-17A production in human MAIT cells.bioRxiv : the preprint server for biology · 2026Article
- Gastrointestinal MAIT cells in chronic HIV-1 infection.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Metabolic control of innate-like T cells.Nature reviews. Immunology · 2026Review
- Multifaceted Roles of IL-26 in Physiological and Pathological Conditions.International journal of molecular sciences · 2025Review
- Sorting endosomes play key roles in presentation ofbioRxiv : the preprint server for biology · 2025Article
- Mucosal-Associated Invariant T Cells: Origins, Biological Functions, Diseases, and Therapeutic Targets.MedComm · 2025Review
- Alveolar macrophage transcriptional signatures associated with resistance to TST/IGRA conversion following Mycobacterium tuberculosis exposure.BMC genomics · 2025Article
- Two-pore channels in MR1-dependent presentation of Mycobacterium tuberculosis infection.PLoS pathogens · 2025Article
- Dual role of mucosal-associated invariant T cells (MAIT) in asthma.The Journal of asthma : official journal of the Association for the Care of Asthma · 2025Review
- Mucosal-associated invariant T-cells in pulmonary pathophysiology.Current opinion in pulmonary medicine · 2025Review
- Immune Checkpoint Receptor Expression Profiles of MAIT Cells in Moderate and Severe COVID-19.Scandinavian journal of immunology · 2025Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 3 countries.
Erin W MeermeierDepartment of Pulmonary and Critical Care Medicine, Oregon Health & Science University, Portland, OR, 97239, USA.ORCID http://orcid.org/0000-0002-9709-7624
Christina L ZhengDepartment of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, OR, 97239, USA.
Jessica G TranVA Portland Health Care System, Portland, OR, 97239, USA.
Shogo SomaDepartment of Pulmonary and Critical Care Medicine, Oregon Health & Science University, Portland, OR, 97239, USA.ORCID http://orcid.org/0000-0002-7990-8403
Aneta H WorleyVA Portland Health Care System, Portland, OR, 97239, USA.
David I WeissDavid Geffen School of Medicine at UCLA, Los Angeles, CA, 90095, USA.ORCID http://orcid.org/0000-0002-2068-7036
Robert L ModlinDivision of Dermatology, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Gwendolyn SwarbrickDepartment of Pulmonary and Critical Care Medicine, Oregon Health & Science University, Portland, OR, 97239, USA.ORCID http://orcid.org/0000-0001-5786-1256
Elham KaramoozDepartment of Pulmonary and Critical Care Medicine, Oregon Health & Science University, Portland, OR, 97239, USA.
Sharon KhuzwayoAfrica Health Research Institute, Durban, South Africa.
Emily B WongAfrica Health Research Institute, Durban, South Africa.ORCID http://orcid.org/0000-0003-4755-5380
Marielle C GoldDepartment of Pulmonary and Critical Care Medicine, Oregon Health & Science University, Portland, OR, 97239, USA.ORCID http://orcid.org/0000-0003-2505-3291
David M LewinsohnDepartment of Pulmonary and Critical Care Medicine, Oregon Health & Science University, Portland, OR, 97239, USA. lewinsod@ohsu.edu.ORCID http://orcid.org/0000-0001-9906-9494
Oregon Health & Science University · USUniversity of California, Los Angeles · USVA Portland Health Care System · USAfrica Health Research Institute · ZAHarvard University · US
Funding
Molecular Analysis of the Host Immune Response in LeprosyR01AI022553 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROBERT L MODLIN · 1989 to 2026
$15.7MTCR GAMMA/DELTA LYMPHOCYTES IN HUMAN SKIN LESIONSR01AR040312 · NIAMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MODLIN, ROBERT L · 1990 to 2025
$10.4MHuman MAIT celis in airway mucosal immune responses to intracellular infectionsU01AI095776 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI LEWINSOHN, DAVID M. · 2011 to 2015
$8.9MMultidisciplinary Research Training in Pulmonary MedicineT32HL083808 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI LEWINSOHN, DAVID M., SLATORE, CHRISTOPHER G. · 2008 to 2025
$5.3MRecognition of Mtb-infected Cells by CD8+ T LymphocytesR01AI048090 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI LEWINSOHN, DAVID M. · 2001 to 2016
$4.2MLung Resident, MR1-Restricted T Cells: Association with Differential Outcomes Following Exposure to M. TuberculosisR01AI134790 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI LEWINSOHN, DAVID M., WALZL, GERHARD · 2018 to 2022
$3.3MDynamics of the cellular and molecular architecture of human pulmonary TB granulomasR01AI166313 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROBERT L MODLIN · 2022 to 2026
$3.2MIL-26 in host defense against infection by intracellular bacteria in skinR01AR073252 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MODLIN, ROBERT L · 2019 to 2023
$2.1MStudies of Mucosal Associated Invariant T (MAIT) cells in people with HIV, TB and HIV/TB co-infection in South AfricaK08AI118538 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI WONG, EMILY BETH · 2015 to 2019
$950kMR1-dependent presentation of Mycobacterium tuberculosis: a unique role for calcium signalingK08AI153359 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI KARAMOOZ, ELHAM · 2020 to 2024
$925kBLRD VA I01 BX000533NHLBI NIH HHS T32 HL083808NIAID NIH HHS K08 AI118538NIAID NIH HHS K08 AI153359NIAID NIH HHS R01 AI022553NIAID NIH HHS R01 AI048090NIAID NIH HHS R01 AI134790NIAID NIH HHS R01 AI166313NIAID NIH HHS U01 AI095776NIAMS NIH HHS R01 AR040312NIAMS NIH HHS R01 AR073252Wellcome TrustWellcome Trust 107752/Z/15/Z
Abstract
Mucosal-associated Invariant T (MAIT) cells are an innate-like T cell subset that recognize a broad array of microbial pathogens, including respiratory pathogens. Here we investigate the transcriptional profile of MAIT cells localized to the human lung, and postulate that MAIT cells may play a role in maintaining homeostasis at this mucosal barrier. Using the MR1/5-OP-RU tetramer, we identified MAIT cells and non-MAIT CD8
Indexed as
Anti-Infective AgentsMucosal-Associated Invariant T CellsAnti-Bacterial AgentsCD8-Positive T-LymphocytesCytokinesHumansLungAnti-Bacterial AgentsAnti-Infective AgentsCytokines
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.