Evidence map›Paper›PMID 36085254›Full record

ArticleChemMedChem2022

Antigiardial Activity of Novel Guanidine Compounds.

Andrew J Stevens, Rebecca Abraham, Kelly A Young, Cecilia C Russell, Siobhann N McCluskey, Jennifer R Baker, Bertha Rusdi, Stephen W Page, Ryan O'Handley, Mark O'Dea and 2 more

Open access · hybridAbstract read
In one paragraph

Article in ChemMedChem, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Ultrastructural Alterations of the Human PathogenPathogens (Basel, Switzerland) · 2023
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Andrew J StevensSchool of Environmental & Life Sciences, The University of Newcastle, University Drive, Callaghan, NSW 2308, Australia.ORCID 0000-0002-5114-9134
Rebecca AbrahamAntimicrobial resistance and Infectious Diseases Laboratory, Harry butler Institute, Murdoch University, 90 South Street, Murdoch, WA 6150, Australia.ORCID 0000-0003-1792-3242
Kelly A YoungSchool of Environmental & Life Sciences, The University of Newcastle, University Drive, Callaghan, NSW 2308, Australia.ORCID 0000-0002-7252-4693
Cecilia C RussellSchool of Environmental & Life Sciences, The University of Newcastle, University Drive, Callaghan, NSW 2308, Australia.ORCID 0000-0001-8401-5856
Siobhann N McCluskeySchool of Environmental & Life Sciences, The University of Newcastle, University Drive, Callaghan, NSW 2308, Australia.ORCID 0000-0003-3609-9316
Jennifer R BakerSchool of Environmental & Life Sciences, The University of Newcastle, University Drive, Callaghan, NSW 2308, Australia.ORCID 0000-0002-9560-301X
Bertha RusdiAntimicrobial resistance and Infectious Diseases Laboratory, Harry butler Institute, Murdoch University, 90 South Street, Murdoch, WA 6150, Australia.ORCID 0000-0002-7109-5460
Stephen W PageNeoculi Pty Ltd., Burwood, 3125 Vic, Australia.ORCID 0000-0001-5312-2149
Ryan O'HandleySchool of Animal and Veterinary Sciences, University of Adelaide, Roseworthy Campus, Mudla Wirra Road, Roseworthy, SA 5371, Australia.ORCID 0000-0002-6046-0688
Mark O'DeaAntimicrobial resistance and Infectious Diseases Laboratory, Harry butler Institute, Murdoch University, 90 South Street, Murdoch, WA 6150, Australia.ORCID 0000-0002-2757-7585
Sam AbrahamAntimicrobial resistance and Infectious Diseases Laboratory, Harry butler Institute, Murdoch University, 90 South Street, Murdoch, WA 6150, Australia.ORCID 0000-0003-0950-2317
Adam McCluskeySchool of Environmental & Life Sciences, The University of Newcastle, University Drive, Callaghan, NSW 2308, Australia.ORCID 0000-0001-7125-863X
University of Newcastle Australia · AUMurdoch University · AUBurwood Hospital · NZThe University of Adelaide · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

From four focused compound libraries based on the known anticoccidial agent robenidine, 44 compounds total were synthesised and screened for antigiardial activity. All active compounds were counter-screened for antibiotic and cytotoxic action. Of the analogues examined, 21 displayed IC

Indexed as

GuanidinesRobenidineAnimalsAnti-Bacterial AgentsGuanidineMetronidazoleMiceAnti-Bacterial AgentsGuanidineGuanidinesMetronidazoleRobenidine

Identifiers

PMID36085254
PMCPMC9828538
OpenAlexW4295296498

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.