Evidence map›Paper›PMID 36084285›Full record

ArticleACS synthetic biology2022

Pseudotyping Bacteriophage P2 Tail Fibers to Extend the Host Range for Biomedical Applications.

Tabitha G Cunliffe, Alan L Parker, Alfonso Jaramillo

Open access · hybridAbstract read
In one paragraph

Article in ACS synthetic biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Tabitha G CunliffeDivision of Cancer and Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, U.K.
Alan L ParkerDivision of Cancer and Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, U.K.ORCID 0000-0002-9302-1761
Alfonso JaramilloSchool of Life Sciences, University of Warwick, Coventry CV4 7AL, U.K.ORCID 0000-0002-6313-9689
Cardiff University · GBParc Científic de la Universitat de València · ESUniversity of Warwick · GB

Funding

Biotechnology and Biological Sciences Research Council BB/M017982/1Biotechnology and Biological Sciences Research Council BB/P020615/1Medical Research Council 515374Medical Research Council 520464
6 · The paper itself

Abstract

Bacteriophages (phages) represent powerful potential treatments against antibiotic-resistant bacterial infections. Antibiotic-resistant bacteria represent a significant threat to global health, with an estimated 70% of infection-causing bacteria being resistant to one or more antibiotics. Developing novel antibiotics against the limited number of cellular targets is expensive and time-consuming, and bacteria can rapidly develop resistance. While bacterial resistance to phage can evolve, bacterial resistance to phage does not appear to spread through lateral gene transfer, and phage may similarly adapt through mutation to recover infectivity. Phages have been identified for all known bacteria, allowing the strain-selective killing of pathogenic bacteria. Here, we re-engineered the

Indexed as

Bacteriophage P2BacteriophagesAnti-Bacterial AgentsHost SpecificityLipopolysaccharidesProteomeAnti-Bacterial AgentsLipopolysaccharidesProteomeantimicrobial resistancebacteriophagechimerapseudotypingretargetingtropism

Identifiers

PMID36084285
PMCPMC9594776
OpenAlexW4296236235

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.