ArticleVeterinary medicine and science2022
First detection and characterisation of sub-genotype XIII.2.1 Newcastle disease virus isolated from backyard chickens in Iran.
Article in Veterinary medicine and science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Long-term surveillance of avian avulavirus in wild birds in China from 2003 to 2020.Virologica Sinica · 2025Article
- Genetic Diversity of Newcastle Disease Virus and Its Implications for Vaccine Development.Veterinary sciences · 2025Review
- Exploring the genetic basis of Newcastle disease virus in chickens: a comprehensive review.Frontiers in immunology · 2025Review
- Analysis of Newcastle disease virus prevalence in wild birds reveals interhost transmission of genotype VI strains.Microbiology spectrum · 2024Article
- Genetic Diversity of Newcastle Disease Virus Involved in the 2021 Outbreaks in Backyard Poultry Farms in Tanzania.Veterinary sciences · 2023Article
- An Outbreak of Newcastle Disease Virus in the Moscow Region in the Summer of 2022.Veterinary sciences · 2023Article
- Article
- The role of the major viral pathogens in a respiratory disease outbreak of broiler flocks in Eastern Iran.Iranian journal of veterinary research · 2023Article
- Construction of Novel Thermostable Chimeric Vaccine Candidates for Genotype VII Newcastle Disease Virus.Viruses · 2022Article
- First detection and characterisation of sub-genotype XIII.2.1 Newcastle disease virus isolated from backyard chickens in Iran.Veterinary medicine and science · 2022Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundNewcastle disease (ND) is an economically significant poultry disease worldwide. During field surveillance for ND in 2010 in Iran, a backyard chicken flock showed clinical signs of ND with 100% mortality.
objectivesWe aimed to characterise genetically, biologically and epidemiologically an exotic virulent ND virus (NDV) detected in Iran.
methodsAfter observing high mortality, dead birds were sampled and then disposed of by burial, and the chicken house was disinfected. Tissue samples were molecularly tested for NDV. The genetic homogeneity of the isolate RT30/2010 was tested by plaque assay, and then a large virus plaque was used for the second step of plaque purification. Fusion and matrix complete genes were sequenced and used for genotyping and epidemiological tracing. We tested biological pathotypes using mean death time (MDT) and intracerebral pathogenicity index (ICPI) assays.
resultsThe isolate formed heterogeneous plaques in chicken embryo fibroblast cells. The second step of plaque purification produced homogeneous and large plaques. Phylogenetic analysis using both genes classified the virus into sub-genotype XIII.2.1. Nucleic acid and amino acid identities of RT30/2010 fusion gene with the closest available isolate SPVC/Karachi/NDV/43 are 97.95% and 98.73%, respectively. Isolate has
conclusionsThis study presents the first detection and characterisation of a velogenic NDV of sub-genotype XIII.2.1 from Iran. Our follow-up surveillance for ND shows that timely virus detection and carcass management have led to the cessation of virus transmission in Iran.
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