High hedgehog signaling is transduced by a multikinase-dependent switch controlling the apico-basal distribution of the GPCR smoothened.

Marina Gonçalves Antunes, Matthieu Sanial, Vincent Contremoulins, Sandra Carvalho, Anne Plessis, Isabelle Becam

Open access · goldAbstract read

In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.1field-weighted citation impact, top 57% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

Smoothened turnover regulated by Hedgehog signaling in Drosophila.bioRxiv : the preprint server for biology · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Marina Gonçalves AntunesUniversité Paris Cité, CNRS, Institut Jacques Monod, Paris, France.ORCID 0000-0003-3818-4434

Matthieu SanialUniversité Paris Cité, CNRS, Institut Jacques Monod, Paris, France.ORCID 0000-0002-0301-4710

Vincent ContremoulinsUniversité Paris Cité, CNRS, Institut Jacques Monod, Paris, France.

Sandra CarvalhoUniversité Paris Cité, CNRS, Institut Jacques Monod, Paris, France.ORCID 0000-0002-8654-0539

Anne PlessisUniversité Paris Cité, CNRS, Institut Jacques Monod, Paris, France.ORCID 0000-0001-9193-7031

Isabelle BecamUniversité Paris Cité, CNRS, Institut Jacques Monod, Paris, France.ORCID 0000-0002-4464-7880

Centre National de la Recherche Scientifique · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The oncogenic G-protein-coupled receptor (GPCR) Smoothened (SMO) is a key transducer of the hedgehog (HH) morphogen, which plays an essential role in the patterning of epithelial structures. Here, we examine how HH controls SMO subcellular localization and activity in a polarized epithelium using the

Indexed as

Drosophila ProteinsHedgehog ProteinsAnimalsDrosophilaDrosophila melanogasterPhosphorylationReceptors, G-Protein-CoupledSmoothened ReceptorDrosophila ProteinsHedgehog ProteinsReceptors, G-Protein-CoupledSmoothened Receptorapico-basal polaritydevelopmental biologyD. melanogasterDrosophilahedgehogphosphorylationprotein traffickingsmoothened

Identifiers

PMID36083801

DOI10.7554/eLife.79843

PMCPMC9462849

OpenAlexW4295079560

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.