ArticleeLife2022
Redox-controlled reorganization and flavin strain within the ribonucleotide reductase R2b-NrdI complex monitored by serial femtosecond crystallography.
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Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Tracking the redox reaction of the iron enzyme ribonucleotide reductase using continuous SerialED and SFX.Structure (London, England : 1993) · 2026Article
- Structural basis of the promiscuity of the unusual Fe(II) and 2-oxoglutarate dependent human aspartate/asparagine-β-hydroxylase.Nature communications · 2026Article
- A Structurally Divergent Class Ia Ribonucleotide Reductase from a Tick-Borne Pathogen.Biochemistry · 2025Article
- Characterization of a second class Ie ribonucleotide reductase.Communications biology · 2025Article
- Manganese uptake by MtsABC contributes to the pathogenesis of human pathogen group A streptococcus by resisting host nutritional immune defenses.Infection and immunity · 2024Article
- Structural biology in the age of X-ray free-electron lasers and exascale computing.Current opinion in structural biology · 2024Review
- Structural insights into the initiation of free radical formation in the Class Ib ribonucleotide reductases in Mycobacteria.Current research in structural biology · 2024Article
- Structure of a ribonucleotide reductase R2 protein radical.Science (New York, N.Y.) · 2023Article
- Why is manganese so valuable to bacterial pathogens?Frontiers in cellular and infection microbiology · 2023Review
- Room temperature crystallography and X-ray spectroscopy of metalloenzymes.Methods in enzymology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
27 authors at 7 institutions in 4 countries.
Juliane JohnDepartment of Biochemistry and Biophysics, Arrhenius Laboratories for Natural Sciences, Stockholm University, Stockholm, Sweden.ORCID 0000-0001-9626-3670
Oskar AureliusDepartment of Biochemistry and Biophysics, Arrhenius Laboratories for Natural Sciences, Stockholm University, Stockholm, Sweden.
Vivek SrinivasDepartment of Biochemistry and Biophysics, Arrhenius Laboratories for Natural Sciences, Stockholm University, Stockholm, Sweden.ORCID 0000-0002-0265-1873
Patricia SauraDepartment of Biochemistry and Biophysics, Arrhenius Laboratories for Natural Sciences, Stockholm University, Stockholm, Sweden.ORCID 0000-0003-2575-9913
In-Sik KimMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, United States.
Asmit BhowmickMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, United States.
Philipp S SimonMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, United States.ORCID 0000-0002-2859-4475
Medhanjali DasguptaMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, United States.
Cindy PhamMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, United States.
Sheraz GulMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, United States.
Kyle D SutherlinMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, United States.
Pierre AllerDiamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, United Kingdom.
Agata ButrynDiamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, United Kingdom.ORCID 0000-0002-5227-4770
Allen M OrvilleDiamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, United Kingdom.ORCID 0000-0002-7803-1777
Mun Hon CheahDepartment of Chemistry - Ångström, Molecular Biomimetics, Uppsala University, Uppsala, Sweden.ORCID 0000-0001-5732-1524
Shigeki OwadaJapan Synchrotron Radiation Research Institute, Sayo-gun, Japan.ORCID 0000-0002-1451-7612
Kensuke TonoJapan Synchrotron Radiation Research Institute, Sayo-gun, Japan.ORCID 0000-0003-1218-3759
Franklin D FullerLCLS, SLAC National Accelerator Laboratory, Menlo Park, United States.
Alexander BatyukLCLS, SLAC National Accelerator Laboratory, Menlo Park, United States.ORCID 0000-0002-9393-2880
Aaron S BrewsterMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, United States.ORCID 0000-0002-0908-7822
Nicholas K SauterMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, United States.ORCID 0000-0003-2786-6552
Vittal K YachandraMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, United States.
Junko YanoMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, United States.ORCID 0000-0001-6308-9071
Ville R I KailaDepartment of Biochemistry and Biophysics, Arrhenius Laboratories for Natural Sciences, Stockholm University, Stockholm, Sweden.ORCID 0000-0003-4464-6324
Jan KernMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, United States.ORCID 0000-0002-7272-1603
Hugo LebretteDepartment of Biochemistry and Biophysics, Arrhenius Laboratories for Natural Sciences, Stockholm University, Stockholm, Sweden.ORCID 0000-0002-8081-181X
Martin HögbomDepartment of Biochemistry and Biophysics, Arrhenius Laboratories for Natural Sciences, Stockholm University, Stockholm, Sweden.ORCID 0000-0001-5574-9383
Lawrence Berkeley National Laboratory · USStockholm University · SEDiamond Light Source · GBSLAC National Accelerator Laboratory · USSPring-8 · JPThe Francis Crick Institute · GBUppsala University · SE
Funding
Taking Snapshots of the Water-Oxidation Reaction by the Mn4Ca Oxygen-Evolving Complex Using X-ray Crystallography and SpectroscopyR01GM055302 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI YACHANDRA, VITTAL · 1997 to 2022
$9.1MDIALS: New Computational Methods to Enable Challenging Crystallographic ExperimentsR01GM117126 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI SAUTER, NICHOLAS K · 2016 to 2023
$6.1MBiological Spectroscopy and Crystallography Using an X-ray Free Electron Laser - Supplemental EquipmentR01GM110501 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Junko Yano · 2014 to 2026
$4.8MHigh throughput sample delivery method for time resolved studies of enzyme reactions with X-ray and complementary techniquesR01GM126289 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI KERN, JAN F · 2017 to 2025
$4.6MHigh-end X-ray Detector System for Femtosecond CrystallographyS10OD023453 · OD · STANFORD UNIVERSITY · PI BOUTET, SEBASTIEN · 2017 to 2017
$1.7MStructure and Function of the Mn Oxygen-Evolving ComplexR56GM055302 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI YACHANDRA, VITTAL · 2009 to 2009
$530kQuantum refinement for improvement of metalloenzyme crystal structuresF32GM133081 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI SUTHERLIN, KYLE D. · 2019 to 2019
$48kBiotechnology and Biological Sciences Research CouncilNIGMS NIH HHS F32 GM133081NIGMS NIH HHS R01 GM055302NIGMS NIH HHS R01 GM110501NIGMS NIH HHS R01 GM117126NIGMS NIH HHS R01 GM126289NIGMS NIH HHS R56 GM055302NIH HHS S10 OD023453Wellcome TrustWellcome Trust 102593
Abstract
Redox reactions are central to biochemistry and are both controlled by and induce protein structural changes. Here, we describe structural rearrangements and crosstalk within the
Indexed as
Ribonucleotide ReductasesCrystallography, X-RayFlavinsOxidation-ReductionSuperoxidesFlavinsRibonucleotide ReductasesSuperoxidesbacillus cereusbiochemistrychemical biologyflavoproteinmetalloproteinmolecular biophysicsoxidoreductaseoxygen activationribonucleotide reductaseserial femtosecond crystallographystructural biology
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.