Evidence map›Paper›PMID 36083474›Full record

ArticleJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2022

Sanguinarine suppresses cell proliferation, migration and invasion in nasopharyngeal carcinoma inhibiting mTOR signaling.

Yang Mengzhe, Zhang Beibei, Liang Zhenqiang, Cheng Nannan, Lü Anqiao, Yang Jianyu, Guo Xingzhe, Bai Xianyu, Huang Yuanjiao, Jiao Aijun and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Plants (Basel, Switzerland) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Yang MengzheSchool of Basic Medical Sciences, Guangxi Medical University, Nanning 530021, China.
Zhang BeibeiInstitute of Biomedical Research, Yunnan University, Kunming 650500, China.
Liang ZhenqiangDepartment of Otolaryngology-Head and Neck Surgery, the Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, China.
Cheng NannanSchool of Basic Medical Sciences, Guangxi Medical University, Nanning 530021, China.
Lü AnqiaoSchool of Basic Medical Sciences, Guangxi Medical University, Nanning 530021, China.
Yang JianyuSchool of Basic Medical Sciences, Guangxi Medical University, Nanning 530021, China.
Guo XingzheSchool of Basic Medical Sciences, Guangxi Medical University, Nanning 530021, China.
Bai XianyuSchool of Basic Medical Sciences, Guangxi Medical University, Nanning 530021, China.
Huang YuanjiaoLife Science Institute, Guangxi Medical University, Nanning 530021, China.
Jiao AijunPharmaceutical College, Guangxi Medical University, Nanning 530021, China.
X U NingDepartment of Neurology, the Fifth Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
Guangxi Medical University · CNYunnan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo confirm the anti-NPC effect of sanguinarine (SA) through a series of wet experiments.

methodsNPC cell viability was determined by proliferation experiment. Cell clone formation experiment, cell scratch test, transwell migration and invasion experiment and flow cytometry-based cell apoptosis assay were further performed. In addition, Western blotting was performed to investigate the cell signaling pathway. All the relevant experimental data were statistically processed using SPSS 16.0 software.

resultsThe results showed that sanguinarine represented a time and dose dependent inhibition effects on NPC cell proliferation including the low differentiated CNE2 cells and high metastatic 5-8F cells, along with the cell cloning ability reduction. In addition, sanguinarine has a certain inhibitory effect on the invasion and migration of NPC cells. Mechanistically, sanguinarine displayed the anti-NPC effects mainly involved into the suppression of mTOR signaling and cell apoptosis, which is closely associated with the tumor growth and metastatic malignancy.

conclusionsCollectively, we discover that sanguinarine is a new high-efficiency anti-NPC monomer of Chinese medicine, with a value for the follow-up pre-clinical research.

Indexed as

Nasopharyngeal NeoplasmsApoptosisBenzophenanthridinesCell Line, TumorCell MovementCell ProliferationHumansIsoquinolinesNasopharyngeal CarcinomaSignal TransductionTOR Serine-Threonine KinasesBenzophenanthridinesIsoquinolinesMTOR protein, humansanguinarineTOR Serine-Threonine Kinasesapoptosisnasopharyngeal carcinomasanguinarineTOR serine-threonine kinases

Identifiers

PMID36083474
PMCPMC9924759
OpenAlexW4295082138

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.