Evidence map›Paper›PMID 36083473›Full record

ArticleJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2022

Efficacy of green tea extract on PC3 prostate cancer cells through upregulation of miR-195 expression and suppression of epithelial to mesenchymal transition.

Fatemeh Safari, Katayoun Dadeh Amirfard

Open access · greenAbstract read
In one paragraph

Article in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Fatemeh SafariDepartment of Biology, Faculty of Science, University of Guilan, Rasht 4193833697, Iran.
Katayoun Dadeh AmirfardDepartment of Microbiology, North Tehran Branch, Islamic Azad University, Tehran 1651153511, Iran.
University of Guilan · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate anticancer efficacy of green tea extract (GTE) on PC3 prostate cancer cells.

methodsBy using quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot methods, the expression of miR-195 and the epithelial to mesenchymal transition (EMT) markers such as E-cadherin and vimentin was analyzed.

resultsBased on the results of 2D and 3D cell culture models, the inhibition of EMT and up regulation of miR-195 expression were detected.

conclusionsOur findings will be helpful to design anti-tumor regimens with natural product original, and more studies will be required to identify the related mechanisms involving anticancer activities of green tea miRNAs.

Indexed as

Biological ProductsMicroRNAsProstatic NeoplasmsCadherinsCell Line, TumorEpithelial-Mesenchymal TransitionGene Expression Regulation, NeoplasticHumansMaleTeaUp-RegulationBiological ProductsCadherinsMicroRNAsMIRN195 microRNA, humanTeaepithelial-mesenchymal transitionGreen tea extractmiR-195 expressionPC3 cancer cells

Identifiers

PMID36083473
PMCPMC9924716
OpenAlexW4295088778

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.