ArticleJournal of the American Chemical Society2022
H-Bond Templated Oligomer Synthesis Using a Covalent Primer.
Article in Journal of the American Chemical Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- Template-directed vertical photopolymerization for construction of triphenylamine-based poly(diacetylene) nanofibers.Nature communications · 2026Article
- Template-Directed Synthesis of Recognition-Encoded Melamine Oligomers Using a Base-Filling Strategy.Journal of the American Chemical Society · 2025Article
- Covalent Template-Directed Synthesis: A Powerful Tool for the Construction of Complex Molecules.Chemical reviews · 2025Review
- Synthetically encoded complementary oligomers.Nature reviews. Chemistry · 2023Review
- Replication of synthetic recognition-encoded oligomers by ligation of trimer building blocks.Organic chemistry frontiers : an international journal of organic chemistry · 2023Article
- Peptide Macrocyclization Guided by Reversible Covalent Templating.Chemistry (Weinheim an der Bergstrasse, Germany) · 2023Article
- Sequence-selective duplex formation and template effect in recognition-encoded oligoanilines.Chemical science · 2023Article
- Recognition-Encoded Synthetic Information Molecules.Accounts of chemical research · 2023Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Template-directed synthesis of nucleic acids in the polymerase chain reaction is based on the use of a primer, which is elongated in the replication process. The attachment of a high affinity primer to the end of a template chain has been implemented for templating the synthesis of triazole oligomers. A covalent ester base-pair was used to attach a primer to a mixed sequence template. The resulting primed template has phenol recognition units on the template, which can form noncovalent base-pairs with phosphine oxide monomers via H-bonding, and an alkyne group on the primer, which can react with the azide group on a phosphine oxide monomer. Competition reactions between azides bearing phosphine oxide and phenol recognition groups were used to demonstrate a substantial template effect, due to H-bonding interactions between the phenols on the template and phosphine oxides on the azide. The largest rate acceleration was observed when a phosphine oxide 2-mer was used, because this compound binds to the template with a higher affinity than compounds that can only make one H-bond. The
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.