Evidence map›Paper›PMID 36082511›Full record

ArticleJournal of cellular and molecular medicine2022

BDA-410 inhibits SARS-CoV-2 main protease activity and viral replication in mammalian cells.

Christopher Schwake, Lindsay McKay, Anthony Griffiths, Christina Scartelli, Robert Flaumenhaft, Athar H Chishti

Open access · goldAbstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Christopher SchwakeDepartment of Developmental, Molecular, and Chemical Biology, Graduate School of Biomedical Sciences, Tufts University School of Medicine, Boston, Massachusetts, USA.
Lindsay McKayNational Emerging Infectious Diseases Laboratories (NEIDL), Department of Microbiology, Boston University, Boston, Massachusetts, USA.
Anthony GriffithsNational Emerging Infectious Diseases Laboratories (NEIDL), Department of Microbiology, Boston University, Boston, Massachusetts, USA.
Christina ScartelliDivision of Hemostasis and Thrombosis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Robert FlaumenhaftDivision of Hemostasis and Thrombosis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Athar H ChishtiDepartment of Developmental, Molecular, and Chemical Biology, Graduate School of Biomedical Sciences, Tufts University School of Medicine, Boston, Massachusetts, USA.ORCID 0000-0003-0335-1861
Beth Israel Deaconess Medical Center · USBoston University · USTufts University · US

Funding

Role of erythrocyte band 3 in malaria adhesionR01HL060961 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI CHISHTI, ATHAR H. · 1998 to 2023
$5.9M
Thiol Isomerases in Hemostasis and ThrombosisR35HL135775 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI FLAUMENHAFT, ROBERT C · 2017 to 2023
$5.5M
Calpain-1 Signaling Pathways in PlateletsR01HL089517 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI CHISHTI, ATHAR H. · 2009 to 2012
$1.6M
NHLBI NIH HHS R01 HL060961NHLBI NIH HHS R01 HL089517NHLBI NIH HHS R35 HL135775
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

COVID-19SARS-CoV-2AnimalsAntiviral AgentsCoronavirus 3C ProteasesHumansMammalsMolecular Docking SimulationSulfonamidesVirus Replication3C-like proteinase, SARS-CoV-2Antiviral AgentsCoronavirus 3C ProteasesN-1-(hydroxy(3-oxo-2-phenyl-1-cyclopropen-1-yl)methyl)-2-methylpropyl-2-benzenesulfonylamino-4-methylpentanamideSulfonamidesBDA-410Calpain-1COVID-19SARS-CoV-2

Identifiers

PMID36082511
PMCPMC9537889
OpenAlexW4295084759

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.