Evidence map›Paper›PMID 36082442›Full record

ArticleAngewandte Chemie (International ed. in English)2022

Regio- and Stereoselective 1,2-Oxyhalogenation of Non-Conjugated Alkynes via Directed Nucleopalladation: Catalytic Access to Tetrasubstituted Alkenes.

Mingyu Liu, Juntao Sun, Tao Zhang, Yi Ding, Ye-Qiang Han, Raúl Martín-Montero, Yu Lan, Bing-Feng Shi, Keary M Engle

Open access · hybridAbstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Cobalt-catalyzed alkyne silylamidation unlocksNational science review · 2026
    Article
  3. Article
  4. Palladium-Catalyzed Dual CspAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Mingyu LiuDepartment of Chemistry, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA.ORCID 0000-0003-4649-7393
Juntao SunDepartment of Chemistry, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA.ORCID 0000-0001-8973-1376
Tao ZhangGreen Catalysis Center and College of Chemistry, Zhengzhou University, Zhengzhou, Henan, 450001, P. R. China.
Yi DingDepartment of Chemistry, Zhejiang University, Hangzhou, Zhejiang, 310027, P. R. China.
Ye-Qiang HanDepartment of Chemistry, Zhejiang University, Hangzhou, Zhejiang, 310027, P. R. China.
Raúl Martín-MonteroDepartment of Chemistry, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA.
Yu LanGreen Catalysis Center and College of Chemistry, Zhengzhou University, Zhengzhou, Henan, 450001, P. R. China.ORCID 0000-0002-2328-0020
Bing-Feng ShiDepartment of Chemistry, Zhejiang University, Hangzhou, Zhejiang, 310027, P. R. China.ORCID 0000-0003-0375-955X
Keary M EngleDepartment of Chemistry, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA.ORCID 0000-0003-2767-6556
Scripps Research Institute · USZhejiang University · CNChongqing University · CNZhengzhou University · CN

Funding

Combinatorial, Catalytic Functionalization of Alkenes and AlkynesR35GM125052 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI ENGLE, KEARY MARK · 2017 to 2021
$2.9M
NIGMS NIH HHS R35 GM125052
6 · The paper itself

Abstract

A catalytic 1,2-oxyhalogenation method that converts non-conjugated internal alkynes into tetrasubstituted alkenes with high regio- and stereoselectivity is described. Mechanistically, the reaction involves a Pd

Indexed as

AlkenesAlkynesAmidesBromidesChloridesIodidesLactamsPalladiumAlkenesAlkynesAmidesBromidesChloridesIodidesLactamsPalladiumAlkeneAlkyne FunctionalizationDirecting GroupOxyhalogenationPalladium

Identifiers

PMID36082442
PMCPMC9588632
OpenAlexW4295083422

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.