SynthesisCytopathology : official journal of the British Society for Clinical Cytology2023
Relevance of the College of American Pathologists guideline for validating whole slide imaging for diagnostic purposes to cytopathology.
Synthesis in Cytopathology : official journal of the British Society for Clinical Cytology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Relevance of the College of American Pathologists guideline for validating whole slide imaging for diagnostic purposes to cytopathology.Cytopathology : official journal of the British Society for Clinical Cytology · 2023Pooled it
- Diagnostic concordance of remote WSI-based thyroid cytology compared to conventional cytological diagnosis: a pilot study.Diagnostic pathology · 2026Article
- Screening efficiency over experience: Rapid target detection in low-power field as a modifiable cognitive biomarker for diagnostic accuracy in digital cytology.Cancer cytopathology · 2026Article
- Bridging the Gap Between Static Histology and Dynamic Organ-on-a-Chip Models.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026Review
- Integration of Digital Cytology in Quality Assurance Programs for Cytopathology.Acta cytologica · 2026Review
- Digital transformation of pathology - the European Society of Pathology expert opinion paper.Virchows Archiv : an international journal of pathology · 2025Article
- Advancements in Digital Cytopathology Since COVID-19: Insights from a Narrative Review of Review Articles.Healthcare (Basel, Switzerland) · 2025Review
- Study on the Transformation Process of Thyroid Fine-Needle Aspiration Liquid-Based Cytology to Whole-Slide Image.Cytopathology : official journal of the British Society for Clinical Cytology · 2025Article
- Crossing the Andes: Challenges and opportunities for digital pathology in Latin America.Journal of pathology informatics · 2024Review
- Digital pathology structure and deployment in Veneto: a proof-of-concept study.Virchows Archiv : an international journal of pathology · 2024Article
- Rapid Remote Online Evaluation in Endoscopic Diagnostics: An Analysis of Biopsy-Proven Respiratory Cytopathology.Diagnostics (Basel, Switzerland) · 2023Article
- Artificial Intelligence-driven Digital Cytology-based Cervical Cancer Screening: Is the Time Ripe to Adopt This Disruptive Technology in Resource-constrained Settings? A Literature Review.Journal of digital imaging · 2023Review
- The slow-paced digital evolution of pathology: lights and shadows from a multifaceted board.Pathologica · 2023Review
- BestCyte® primary screening of 500 ThinPrep Pap Test thin-layers: 3 Cytologists' Interobserver diagnostic concordance with predicate manual microscopy relative to Truth Reference diagnoses defining NILM, ASCUS+, LSIL+, and ASCH+ thresholds for specificity, sensitivity, and equivalency grading.Journal of pathology informatics · 2023Article
- Comparison of FNA-based conventional cytology specimens and digital image analysis in assessment of pancreatic lesions.CytoJournal · 2023Article
- The experience of introducing telepathology in Mongolia.Journal of pathology informatics · 2023Article
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Whole slide imaging (WSI) allows pathologists to view virtual versions of slides on computer monitors. With increasing adoption of digital pathology, laboratories have begun to validate their WSI systems for diagnostic purposes according to reference guidelines. Among these the College of American Pathologists (CAP) guideline includes three strong recommendations (SRs) and nine good practice statements (GPSs). To date, the application of WSI to cytopathology has been beyond the scope of the CAP guideline due to limited evidence. Herein we systematically reviewed the published literature on WSI validation studies in cytology. A systematic search was carried out in PubMed-MEDLINE and Embase databases up to November 2021 to identify all publications regarding validation of WSI in cytology. Each article was reviewed to determine if SRs and/or GPSs recommended by the CAP guideline were adequately satisfied. Of 3963 retrieved articles, 25 were included. Only 4/25 studies (16%) satisfied all three SRs, with only one publication (1/25, 4%) fulfilling all three SRs and nine GPSs. Lack of a suitable validation dataset was the main missing SR (16/25, 64%) and less than a third of the studies reported intra-observer variability data (7/25, 28%). Whilst the CAP guideline for WSI validation in clinical practice helped the widespread adoption of digital pathology, more evidence is required to routinely employ WSI for diagnostic purposes in cytopathology practice. More dedicated validation studies satisfying all SRs and/or GPSs recommended by the CAP are needed to help expedite the use of WSI for primary diagnosis in cytopathology.
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