Evidence map›Paper›PMID 36082404›Full record

ArticleHead & neck2022

Preclinical feasibility of robot-assisted sentinel lymph node biopsy using multi-modality magnetic and fluorescence guidance in the head and neck.

Giri Krishnan, Aidan Cousins, Nguyen Pham, Valentina Milanova, Melanie Nelson, Shridhar Krishnan, Nynke S van den Berg, Anil Shetty, Eben L Rosenthal, Peter-John Wormald and 3 more

Abstract read
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In one paragraph

Article in Head & neck, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Giri KrishnanDepartment of Otolaryngology, Head and Neck Surgery, The University of Adelaide, Adelaide, South Australia, Australia.
Aidan CousinsFuture Industries Institute, University of South Australia, Mawson Lakes Campus, Adelaide, South Australia, Australia.ORCID 0000-0002-2986-422X
Nguyen PhamKey Centre for Polymers and Colloids, School of Chemistry and University of Sydney Nano Institute, The University of Sydney, Sydney, New South Wales, Australia.
Valentina MilanovaFuture Industries Institute, University of South Australia, Mawson Lakes Campus, Adelaide, South Australia, Australia.
Melanie NelsonFerronova Pty Ltd, Adelaide, South Australia, Australia.
Shridhar KrishnanDepartment of Oral and Maxillofacial Surgery, The University of Adelaide, Adelaide, South Australia, Australia.
Nynke S van den BergDepartment of Otolaryngology-Division of Head and Neck Surgery, Stanford University School of Medicine, Stanford, California, USA.
Anil ShettyFerronova Pty Ltd, Adelaide, South Australia, Australia.
Eben L RosenthalDepartment of Otolaryngology-Division of Head and Neck Surgery, Stanford University School of Medicine, Stanford, California, USA.
Peter-John WormaldDepartment of Otolaryngology, Head and Neck Surgery, The University of Adelaide, Adelaide, South Australia, Australia.
Benjamin ThierryFuture Industries Institute, University of South Australia, Mawson Lakes Campus, Adelaide, South Australia, Australia.
Andrew ForemanDepartment of Otolaryngology, Head and Neck Surgery, The University of Adelaide, Adelaide, South Australia, Australia.
Suren KrishnanDepartment of Otolaryngology, Head and Neck Surgery, The University of Adelaide, Adelaide, South Australia, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSentinel lymph node biopsy (SLNB) is a staging procedure dependent on accurate mapping of draining lymphatics via tracers. Robot-assisted SLNB enables access to multiple neck levels with a single incision and intraoperative fluorescence guidance to the SLN.

methodsLymphatic mapping in swine was done using a magnetic tracer and fluorescent dye, injected into the tongue. MRI preoperatively mapped lymphatic spread of the magnetic tracer. Dissection was performed using a da Vinci Xi robot guided by fluorescence-imaging of the dye.

resultsRobot-assisted SLNB was successfully performed in all animals (n = 5). A novel MRI protocol differentiated SLNs (n = 6) from lower echelon nodes (n = 11) based on flow progression. Fluorescence imaging provided valuable intraoperative guidance and correlated with magnetic-positive nodes.

conclusionsThis study demonstrates preclinical feasibility of a robot-assisted approach to SLNB using magnetic and fluorescent tracers in the head and neck, enabling both preoperative mapping and intraoperative guidance.

Indexed as

RoboticsSentinel Lymph Node BiopsyAnimalsFeasibility StudiesFluorescenceFluorescent DyesIndocyanine GreenLymph NodesSwineFluorescent DyesIndocyanine Greenindocyanine greenmagnetic nanoparticlesrobotic surgerysentinel lymph node biopsytranslational science

Identifiers

PMID36082404
PMCPMC9825899

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.