ReviewHeliyon2022
Extraction of natural hydroxyapatite for biomedical applications-A review.
Review in Heliyon, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 118 citations in OpenAlex.
- Comparative evaluation of biogenic hydroxyapatite derived from fish bones and synthetic hydroxyapatite for the removal of flucloxacillin sodium.Discover nano · 2026Article
- Hydroxyapatite-Polysaccharide Composites Synthesized from Maize Lime-Cooking Wastewater for Bone Tissue Engineering.Journal of functional biomaterials · 2026Article
- Selective photocatalytic mineralization of organic pollutants using eggshell- and seashell-based hydroxyapatite-TiOScientific reports · 2026Article
- Biogenic nanohydroxyapatite derived from Channa striata fish bones using alkaline hydrolysis and calcination.Scientific reports · 2026Article
- Mollusk shells as marine bioactive materials: Composition, bioactivities, and prospects for food and health applications.iScience · 2026Review
- Comparison of the Caries Remineralizing Effects of Dentifrices Based on Natural Hydroxyapatite, Synthetic Hydroxyapatite, and Fluoride: A pH Cycling Study.Biomimetics (Basel, Switzerland) · 2026Article
- The potential use of hydroxyapatite from sea coral as a bone substitute: a systematic review.Archives of craniofacial surgery · 2025Article
- Influence of calcination temperature on equine bone hydroxyapatite structure and lead adsorption efficiency.Scientific reports · 2025Article
- MIL-53 MOF on Sustainable Biomaterial for Antimicrobial Evaluation AgainstJournal of functional biomaterials · 2025Article
- Tribological properties of hydroxyapatite-coated nanorods on Ti-6Al-4V surfaces.Scientific reports · 2025Article
- Novel Applications of Natural Biomaterials in Dentistry-Properties, Uses, and Development Perspectives.Materials (Basel, Switzerland) · 2025Review
- 3D scaffold of hydroxyapatite/β tricalcium phosphate from mussel shells: Synthesis, characterization and cytotoxicity.Heliyon · 2025Article
- Comparative study of bovine and synthetic hydroxyapatite in micro- and nanosized on osteoblasts action and bone growth.PloS one · 2025Article
- Critical-size bone defect repair with three types of nano-hydroxyapatite scaffolds: AnBioImpacts : BI · 2025Article
- Article
- Natural hydroxyapatite-based nanobiocomposites and their biomaterials-to-cell interaction for bone tissue engineering.Discover nano · 2024Review
- Hydroxyapatite-Based Natural Biopolymer Composite for Tissue Regeneration.Materials (Basel, Switzerland) · 2024Review
- Synthetic or Natural (Bio-Based) Hydroxyapatite? A Systematic Comparison between Biomimetic Nanostructured Coatings Produced by Ionized Jet Deposition.Nanomaterials (Basel, Switzerland) · 2024Article
- Article
- Biocompatibility and Osteogenic Activity of Samarium-Doped Hydroxyapatite-Biomimetic Nanoceramics for Bone Regeneration Applications.Biomimetics (Basel, Switzerland) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hydroxyapatite has recently played a crucial role in the sustainable development of biomedical applications. Publications related to hydroxyapatite as filler for biopolymers have exhibited an increasing trend due to the expanding research output. Based on the latest publications, the authors reviewed the research trends regarding hydroxyapatite use in biomedical applications. Analysis of the Scopus database using the keywords 'hydroxyapatite" and "biomedical applications" determined that 1,714 papers were produced between 2012 and 2021. The number of publications related to these keywords more than doubled between 2012 (99) and 2021 (247). The hydrothermal method, solid-state reactions, the sol-gel process, emulsion, micro-emulsion, and mostly chemical precipitation were used to produce synthetic hydroxyapatite. Meanwhile, calcination, alkaline hydrolysis, precipitation, hydrothermal, and a combination of these techniques were used in producing natural hydroxyapatite. Studies in the current literature reveal that shell-based animal sources have been frequently used as hydroxyapatite resources during investigations concerning biomedical applications, while calcination was the extraction method most often applied. Essential trace elements of fish bone, oyster shell, and eggshell were also found in hydroxyapatite powder. Abalone mussel shell and eggshell showed Ca/P ratios closer to the stoichiometric ratio due to the use of effective extraction methods such as manipulating aging time or stirring process parameters. This review should greatly assist by offering scientific insights to support all the recommended future research works, not only that associated with biomedical applications.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.