Evidence map›Paper›PMID 36082160›Full record

ArticleFrontiers in bioengineering and biotechnology2022

Cartilage regeneration using improved surface electrospun bilayer polycaprolactone scaffolds loaded with transforming growth factor-beta 3 and rabbit muscle-derived stem cells.

Mantas Malinauskas, Lina Jankauskaite, Lauryna Aukstikalne, Lauryna Dabasinskaite, Augustinas Rimkunas, Tomas Mickevicius, Alius Pockevicius, Edvinas Krugly, Dainius Martuzevicius, Darius Ciuzas and 2 more

Abstract read
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mantas MalinauskasInstitute of Physiology and Pharmacology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Lina JankauskaiteInstitute of Physiology and Pharmacology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Lauryna AukstikalneInstitute of Physiology and Pharmacology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Lauryna DabasinskaiteFaculty of Chemical Technology, Kaunas University of Technology, Kaunas, Lithuania.
Augustinas RimkunasInstitute of Physiology and Pharmacology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Tomas MickeviciusInstitute of Physiology and Pharmacology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Alius PockeviciusDepartment of Veterinary Pathobiology, Veterinary Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Edvinas KruglyFaculty of Chemical Technology, Kaunas University of Technology, Kaunas, Lithuania.
Dainius MartuzeviciusFaculty of Chemical Technology, Kaunas University of Technology, Kaunas, Lithuania.
Darius CiuzasFaculty of Chemical Technology, Kaunas University of Technology, Kaunas, Lithuania.
Odeta BaniukaitieneFaculty of Chemical Technology, Kaunas University of Technology, Kaunas, Lithuania.
Arvydas UsasInstitute of Physiology and Pharmacology, Lithuanian University of Health Sciences, Kaunas, Lithuania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polycaprolactone (PCL) has recently received significant attention due to its mechanical strength, low immunogenicity, elasticity, and biodegradability. Therefore, it is perfectly suitable for cartilage tissue engineering. PCL is relatively hydrophobic in nature, so its hydrophilicity needs to be enhanced before its use in scaffolding. In our study, first, we aimed to improve the hydrophilicity properties after the network of the bilayer scaffold was formed by electrospinning. Electrospun bilayer PCL scaffolds were treated with ozone and further loaded with transforming growth factor-beta 3 (TGFβ3).

Indexed as

cartilage regenerationcell-scaffold constructozone treatmentPCL scaffoldsrabbit MDSCstransforming growth factor-beta 3

Identifiers

PMID36082160
PMCPMC9445302

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.