ArticleFrontiers in endocrinology2022
Causal relationships of obesity on musculoskeletal chronic pain: A two-sample Mendelian randomization study.
Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05816798 (Photobiomodulation in Chronic Knee Pain in Patients Who Are in PreRehabilitation for Bariatric Surgery), which is not on this map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Photobiomodulation in Chronic Knee Pain in Patients Who Are in PreRehabilitation for Bariatric Surgery: Double Blind, Randomized, Controlled Placebo Clinical Trial
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Association between body mass index and musculoskeletal disorders among agricultural workers: a systematic review.BMC public health · 2026Pooled it
- Associations between lifestyle-related risk factors and back pain: a systematic review and meta-analysis of Mendelian randomization studies.BMC musculoskeletal disorders · 2024Pooled it
- Longitudinal associations between BMI changes and musculoskeletal pain in older European males and females.International journal of obesity (2005) · 2026Article
- Obesity and female reproductive health in Asian population.Obesity pillars · 2026Review
- Review
- The Relation Between Quality of Life, Functional Impairment and Nutritional Status in Older People.Healthcare (Basel, Switzerland) · 2026Article
- Joint Pain Outcomes After Metabolic and Bariatric Surgery in Patients With and Without Hypermobility.Obesity science & practice · 2026Article
- Differences in chronic musculoskeletal pain among male and female Brazilian university professors.Revista da Escola de Enfermagem da U S P · 2026Article
- The effects of immune cells and blood metabolites on kidney stones: a bidirectional two-sample Mendelian randomization study and mediation analysis.International urology and nephrology · 2025Article
- Association between the body roundness index and chronic pain among adults in the United States: a cross-sectional study.Annals of medicine and surgery (2012) · 2025Article
- Observational
- Predictors of Postoperative Outcomes after Arthroscopic Partial Meniscectomy: A Retrospective Analysis.Orthopaedic surgery · 2024Article
- Obesity aggravates the role of C-reactive protein on knee pain: A cross-sectional analysis with NHANES data.Immunity, inflammation and disease · 2024Article
- Lumbar Paravertebral Muscle Pain Management Using Kinesitherapy and Electrotherapeutic Modalities.Healthcare (Basel, Switzerland) · 2024Article
- Global burden of low back pain and its attributable risk factors from 1990 to 2021: a comprehensive analysis from the global burden of disease study 2021.Frontiers in public health · 2024Article
- Hip and waist circumference correlations with demographic factors and pain intensity in patients with chronic pain.Pain management · 2024Article
- Association between waist circumference and chronic pain: insights from observational study and two-sample Mendelian randomization.Frontiers in nutrition · 2024Article
- Unraveling the causal role of immune cells in gastrointestinal tract cancers: insights from a Mendelian randomization study.Frontiers in immunology · 2024Article
- Epidemiology of musculoskeletal disorders among iranian adults: results from a non-communicable disease cohort study.BMC musculoskeletal disorders · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The association between obesity and musculoskeletal chronic pain has attracted much attention these days; however, the causal relationship between them is uncertain. Hence, this study performed a Mendelian randomization (MR) analysis to investigate the causal effects of body mass index (BMI), waist circumference (WC), hip circumference (HC), and waist-to-hip ratio (WHR) on knee pain, hip pain, and back pain. Materials and methods: The summary data for obesity and musculoskeletal chronic pain came from the genome-wide association study datasets. Significant and independent ( Results: The positive causal effects of BMI on knee pain (odds ratio (OR) = 1.049; 95% CI: 1.034 to 1.063; Conclusions: This study revealed that BMI was positively related to knee, hip, and back pain and that WC and HC were positively associated with knee and hip pain, while WHR was not related to any type of musculoskeletal chronic pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.