ArticleFrontiers in nutrition2022
Genetic association between circulating selenium level and the risk of schizophrenia in the European population: A two-sample Mendelian randomization study.
Article in Frontiers in nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Pooled it
- Shared genetic architecture and causal relationship between frailty and schizophrenia.Schizophrenia (Heidelberg, Germany) · 2025Article
- Ferroptosis in schizophrenia: Mechanisms and therapeutic potentials (Review).Molecular medicine reports · 2025Review
- Unraveling the Link: Mendelian Randomization Reveals Causal Relationship Between Selenium and Metabolic Syndrome.Biological trace element research · 2025Article
- Strong associations of serum selenoprotein P with all-cause mortality and mortality due to cancer, cardiovascular, respiratory and gastrointestinal diseases in older German adults.European journal of epidemiology · 2024Article
- The causal effect of iron status on risk of anxiety disorders: A two-sample Mendelian randomization study.PloS one · 2024Article
- Association of circulating minerals and vitamins with pregnancy complications: a Mendelian randomization study.Frontiers in nutrition · 2024Article
- The causal effects between selenium levels and the brain cortical structure: A two-sample Mendelian randomization study.Brain and behavior · 2023Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The association between circulating the selenium level and the risk of schizophrenia remains unclear. Objective: To determine the relationship between the circulating selenium level and the risk of schizophrenia, using the Mendelian Randomization method in the European population. Methods: Single nucleotide polymorphisms (SNPs) associated with the circulating selenium level were identified at Results: The circulating selenium level was associated with decreased risk of schizophrenia by the IVW method (OR: 0.906, 95% CI:0.867-0.947). MR Egger, weighted median, and MR PRESSO methods got similar results. No heterogeneity was detected by the Cochran's Q-test, and no single SNP was driving the overall effect by leave-one-out analysis. Conclusion: Our study provides support for the genetic relationship between the circulating selenium level and schizophrenia; the decreased circulating selenium level was associated with an elevated risk of schizophrenia.
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