Evidence map›Paper›PMID 36081988›Full record

ArticleFrontiers in genetics2022

Early-Life Exposure of Pigs to Topsoil Alters miRNA and mRNA Expression in Peripheral Blood Mononuclear Cells.

M M De Souza, D A Koltes, H Beiki, M A Sales, T Tsai, C V Maxwell, J Zhao, J E Koltes

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

M M De SouzaDepartment of Animal Science, Iowa State University, Ames, IA, United States.
D A KoltesDepartment of Animal Science, Iowa State University, Ames, IA, United States.
H BeikiDepartment of Animal Science, Iowa State University, Ames, IA, United States.
M A SalesDepartment of Animal Science, University of Arkansas-Division of Agriculture, Fayetteville, AR, United States.
T TsaiDepartment of Animal Science, University of Arkansas-Division of Agriculture, Fayetteville, AR, United States.
C V MaxwellDepartment of Animal Science, University of Arkansas-Division of Agriculture, Fayetteville, AR, United States.
J ZhaoDepartment of Animal Science, University of Arkansas-Division of Agriculture, Fayetteville, AR, United States.
J E KoltesDepartment of Animal Science, Iowa State University, Ames, IA, United States.
Iowa State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exposure to less-hygienic conditions during early childhood has been associated with stimulation and development of the immune system. A recent study indicated that exposure of piglets to soil-borne microbes during lactation was related with modulation of gut microbiota and immune function. To identify the potential molecular mechanisms and pathways impacted by early-life topsoil exposure, we analyzed the messenger RNA (mRNA) and micro-RNA (miRNA) expression in peripheral blood mononuclear cells (PBMCs) from these piglets. Total RNA was extracted from the PBMCs of piglets exposed to topsoil only from d 4-d 21 of life (mRNA

Indexed as

hygiene hypothesisimmune systemlivestockmicrobiotaperipheral blood mononuclear cellsRNA sequencing

Identifiers

PMID36081988
PMCPMC9445269
OpenAlexW4292823945

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.