Evidence map›Paper›PMID 36081798›Full record

ArticleFrontiers in microbiology2022

Composition and diversity of gut microbiota in diabetic retinopathy.

Jianhao Bai, Zhongqi Wan, Yuanyuan Zhang, Tianyu Wang, Yawen Xue, Qing Peng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 4 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 4 syntheses or guidelines pooled it, 61 citations in OpenAlex.

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  3. Short-Chain Fatty Acids and the Gut-Retina Connection: A Systematic Review.International journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jianhao BaiDepartment of Ophthalmology, Shanghai Tenth People's Hospital of Tongji University, Tongji University School of Medicine, Shanghai, China.
Zhongqi WanDepartment of Ophthalmology, Shanghai Tenth People's Hospital of Tongji University, Tongji University School of Medicine, Shanghai, China.
Yuanyuan ZhangDepartment of Ophthalmology, Shanghai Tenth People's Hospital of Tongji University, Tongji University School of Medicine, Shanghai, China.
Tianyu WangDepartment of Ophthalmology, Shanghai Tenth People's Hospital of Tongji University, Tongji University School of Medicine, Shanghai, China.
Yawen XueDepartment of Ophthalmology, Shanghai Tenth People's Hospital of Tongji University, Tongji University School of Medicine, Shanghai, China.
Qing PengDepartment of Ophthalmology, Shanghai Tenth People's Hospital of Tongji University, Tongji University School of Medicine, Shanghai, China.
Shanghai Tenth People's Hospital · CNTongji University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Diabetic retinopathy (DR) is one of the most common complications of type 2 diabetes mellitus. The current study investigates the composition, structure, and function of gut microbiota in DR patients and explores the correlation between gut microbiota and clinical characteristics of DR. Methods: A total of 50 stool samples were collected from 50 participants, including 25 DR patients and 25 healthy controls (HCs). 16S ribosomal RNA gene sequencing was used to analyze the gut microbial composition in these two groups. DNA was extracted from the fecal samples using the MiSeq platform. Results: The microbial structure and composition of DR patients were different from that of HCs. The microbial richness of gut microbiota in DR was higher than that of normal individuals. The alterations of microbiome of DR patients were associated with disrupted Firmicutes, Bacteroidetes, Synergistota, and Desulfobacterota phyla. In addition, increased levels of Conclusion: The altered composition and function of gut microbiota in DR patients indicated that gut microbiome could be used as non-invasive biomarkers, improve clinical diagnostic methods, and identify putative therapeutic targets for DR.

Indexed as

16S rRNA gene amplicon sequencingbiomarkerdiabetic retinopathygut microbiotahuman

Identifiers

PMID36081798
PMCPMC9445585
OpenAlexW4292716475

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.