Evidence map›Paper›PMID 36081657›Full record

ArticleFrontiers in neuroscience2022

Myelin damage and cortical atrophy in watershed regions in patients with moyamoya angiopathy.

Elena Filimonova, Konstantin Ovsiannikov, Alexsey Sosnov, Artem Perfilyev, Rustam Gafurov, Dmitriy Galaktionov, Anatoliy Bervickiy, Vitaly Kiselev, Jamil Rzaev

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Elena FilimonovaFederal Center of Neurosurgery, Novosibirsk, Russia.
Konstantin OvsiannikovFederal Center of Neurosurgery, Novosibirsk, Russia.
Alexsey SosnovFederal Center of Neurosurgery, Novosibirsk, Russia.
Artem PerfilyevFederal Center of Neurosurgery, Novosibirsk, Russia.
Rustam GafurovFederal Center of Neurosurgery, Novosibirsk, Russia.
Dmitriy GalaktionovFederal Center of Neurosurgery, Novosibirsk, Russia.
Anatoliy BervickiyFederal Center of Neurosurgery, Novosibirsk, Russia.
Vitaly KiselevFederal Center of Neurosurgery, Novosibirsk, Russia.
Jamil RzaevFederal Center of Neurosurgery, Novosibirsk, Russia.
Federal Neurosurgical Center Novosibirsk · RUNovosibirsk State Medical University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Despite it being known that chronic ischemia results in myelin damage and gray matter atrophy, data regarding patients with moyamoya angiopathy is limited. We hypothesized that chronic ischemia in moyamoya angiopathy leads to myelin damage, especially in anterior watershed regions, as well as cortical atrophy in these areas. Materials and methods: Twenty adult patients with moyamoya angiopathy and 17 age- and sex-matched healthy controls were evaluated using the T1w/T2w mapping method and surface-based MR-morphometry. The T1w/T2w signal intensity ratio, which reflects the white matter integrity, and the cortical thickness, were calculated in watershed regions and compared between the patients and controls. In the patients with moyamoya angiopathy, the correlations between these parameters and the Suzuki stage were also evaluated. Results: The regional T1w/T2w ratio values from centrum semiovale in patients with MMA were significantly lower than those in healthy controls ( Conclusion: T1w/T2w mapping revealed that myelin damage exists in watershed regions in patients with moyamoya angiopathy, in association with cortical atrophy according to MR-morphometry. These changes were correlated with the disease stage.

Indexed as

demyelinationFreeSurfermagnetic resonance imaging (MRI)moyamoya angiopathy (MMA)MR-morphometryT1w/T2w ratio

Identifiers

PMID36081657
PMCPMC9445365
OpenAlexW4292822818

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.