Evidence map›Paper›PMID 36081510›Full record

ArticleFrontiers in immunology2022

Cyclic di-AMP as endogenous adjuvant enhanced BCG-induced trained immunity and protection against

Huanhuan Ning, Jian Kang, Yanzhi Lu, Xuan Liang, Jie Zhou, Rui Ren, Shan Zhou, Yong Zhao, Yanling Xie, Lu Bai and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Ag85B with c-di-AMP as mucosal adjuvant showed immunotherapeutic effects on persistent Mycobacterium tuberculosis infection in mice.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2024
    Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 1 country.

Huanhuan NingDepartment of Microbiology and Pathogen Biology, School of Preclinical Medicine, Air Force Medical University, Xi'an, China.
Jian KangDepartment of Microbiology and Pathogen Biology, School of Preclinical Medicine, Air Force Medical University, Xi'an, China.
Yanzhi LuDepartment of Microbiology and Pathogen Biology, School of Preclinical Medicine, Air Force Medical University, Xi'an, China.
Xuan LiangDepartment of Microbiology and Pathogen Biology, School of Preclinical Medicine, Air Force Medical University, Xi'an, China.
Jie ZhouDepartment of Endocrinology, Xijing Hospital, Air Force Medical University, Xi'an, China.
Rui RenDepartment of Microbiology and Pathogen Biology, School of Preclinical Medicine, Air Force Medical University, Xi'an, China.
Shan ZhouDepartment of Clinical Laboratory, Xijing Hospital, Air Force Medical University, Xi'an, China.
Yong ZhaoLaboratory Animal Center, Air Force Medical University, Xi'an, China.
Yanling XieDepartment of Microbiology and Pathogen Biology, School of Preclinical Medicine, Air Force Medical University, Xi'an, China.
Lu BaiDepartment of Microbiology and Pathogen Biology, School of Preclinical Medicine, Air Force Medical University, Xi'an, China.
Linna ZhangDepartment of Physiology, Basic Medical School, Ningxia Medical University, Yinchuan, China.
Yali KangDepartment of Microbiology and Pathogen Biology, School of Preclinical Medicine, Air Force Medical University, Xi'an, China.
Xiaojing GaoDepartment of Microbiology and Pathogen Biology, School of Preclinical Medicine, Air Force Medical University, Xi'an, China.
Mingze XuDepartment of Microbiology and Pathogen Biology, School of Preclinical Medicine, Air Force Medical University, Xi'an, China.
Yanling MaCollege of Life Sciences, Northwest University, Xi'an, China.
Fanglin ZhangDepartment of Microbiology and Pathogen Biology, School of Preclinical Medicine, Air Force Medical University, Xi'an, China.
Yinlan BaiDepartment of Microbiology and Pathogen Biology, School of Preclinical Medicine, Air Force Medical University, Xi'an, China.
Air Force Medical University · CNNingxia Medical University · CNNorthwest University · CNXijing Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacillus Calmette-Guérin (BCG) is a licensed prophylactic vaccine against tuberculosis (TB). Current TB vaccine efforts focus on improving BCG effects through recombination or genetic attenuation and/or boost with different vaccines. Recent years, it was revealed that BCG could elicit non-specific heterogeneous protection against other pathogens such as viruses through a process termed trained immunity. Previously, we constructed a recombinant BCG (rBCG-DisA) with elevated c-di-AMP as endogenous adjuvant by overexpressing di-adenylate cyclase of

Indexed as

Cyclic AMPMycobacterium bovisMycobacterium tuberculosisTuberculosis, Lymph NodeAcyltransferasesAdenosine MonophosphateAdjuvants, ImmunologicAdjuvants, PharmaceuticAnimalsAntigens, BacterialBCG VaccineCytokinesDinucleoside PhosphatesMiceMice, Inbred C57BLVaccines, SyntheticAcyltransferasesAdenosine MonophosphateAdjuvants, ImmunologicAdjuvants, PharmaceuticAntigens, BacterialBCG VaccineCyclic AMPcyclic diadenosine phosphateCytokinesDinucleoside PhosphatesVaccines, SyntheticadjuvantBacillus Calmette-Guérincyclic di-AMPMycobacterium tuberculosistrained immunity

Identifiers

PMID36081510
PMCPMC9445367
OpenAlexW4292823253

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.