Evidence map›Paper›PMID 36081452›Full record

ArticleJournal of immunology research2022

Trametenolic Acid Ameliorates the Progression of Diabetic Nephropathy in db/db Mice via Nrf2/HO-1 and NF-

Qi Duan, Lingling Tian, Jiabing Feng, Xinbo Ping, Lihong Li, Hasnaa Yaigoub, Rongshan Li, Yafeng Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. NRF2 Dysregulation and Therapeutic Insights Across Chronic Kidney Diseases.International journal of molecular sciences · 2025
    Review
  5. Review
  6. Review
  7. Effects ofFrontiers in pharmacology · 2024
    Article
  8. Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Qi DuanShanxi Key Laboratory of Kidney Disease, Shanxi Provincial People's Hospital (Fifth Hospital) of Shanxi Medical University, Taiyuan, 030012 Shanxi, China.ORCID https://orcid.org/0000-0001-6378-5472
Lingling TianThe Third Clinical College, Shanxi University of Chinese Medicine, Taiyuan, 030000 Shanxi, China.ORCID https://orcid.org/0000-0001-5067-1572
Jiabing FengShanxi Key Laboratory of Kidney Disease, Shanxi Provincial People's Hospital (Fifth Hospital) of Shanxi Medical University, Taiyuan, 030012 Shanxi, China.ORCID https://orcid.org/0000-0001-6290-5399
Xinbo PingShanxi Key Laboratory of Kidney Disease, Shanxi Provincial People's Hospital (Fifth Hospital) of Shanxi Medical University, Taiyuan, 030012 Shanxi, China.ORCID https://orcid.org/0000-0003-4444-0780
Lihong LiLaboratory Animal Center, Shanxi Provincial People's Hospital (Fifth Hospital) of Shanxi Medical University, Taiyuan, 030012 Shanxi, China.ORCID https://orcid.org/0000-0001-6024-9885
Hasnaa YaigoubSchool of Life Sciences, Institutes of Biomedical Sciences, Shanxi University, Taiyuan 030006, China.ORCID https://orcid.org/0000-0001-9517-9821
Rongshan LiShanxi Key Laboratory of Kidney Disease, Shanxi Provincial People's Hospital (Fifth Hospital) of Shanxi Medical University, Taiyuan, 030012 Shanxi, China.ORCID https://orcid.org/0000-0002-8082-4389
Yafeng LiShanxi Key Laboratory of Kidney Disease, Shanxi Provincial People's Hospital (Fifth Hospital) of Shanxi Medical University, Taiyuan, 030012 Shanxi, China.ORCID https://orcid.org/0000-0002-7500-0959
Shanxi Medical University · CNShanxi University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic nephropathy (DN) is a fatal complication of diabetes and the main cause of end-stage renal disease. Due to the suboptimal effects of current treatments, there is an urgent need to develop new therapeutic strategies for DN. Trametenolic acid (TA), a lanostane-type tetracyclic triterpenoid, is one of the main active ingredients extracted from the natural product

Indexed as

Diabetes MellitusDiabetic NephropathiesTriterpenesAlbuminsAnimalsAntioxidantsBody WeightGlutathioneHeme Oxygenase-1Interleukin-6MiceNF-E2-Related Factor 2NF-kappa BOxidative StressSuperoxide DismutaseTumor Necrosis Factor-alphaAlbuminsAntioxidantsGlutathioneHeme Oxygenase-1Interleukin-6NF-E2-Related Factor 2NF-kappa BSuperoxide DismutaseTriterpenesTumor Necrosis Factor-alpha

Identifiers

PMID36081452
PMCPMC9448586
OpenAlexW4293773621

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.