Evidence map›Paper›PMID 36081434›Full record

ArticleComputational and mathematical methods in medicine2022

Screening of Differentially Expressed Iron Death-Related Genes and the Construction of Prognosis Model in Patients with Renal Clear Cell Carcinoma.

Ding Wu, Zhenyu Xu, Zhan Shi, Ping Li, Huichen Lv, Jie Huang, Dian Fu

RetractedOpen access · hybridAbstract readRetracted Publication
In one paragraph

Article in Computational and mathematical methods in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ding WuDepartment of Urology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China.
Zhenyu XuDepartment of Urology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China.ORCID https://orcid.org/0000-0003-0205-6537
Zhan ShiThe Comprehensive Cancer Centre of Drum Tower Hospital, Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University, Nanjing 210008, China.
Ping LiDepartment of Urology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China.
Huichen LvDepartment of Urology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China.
Jie HuangDepartment of Urology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China.
Dian FuDepartment of Urology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China.ORCID https://orcid.org/0000-0002-1370-0853
Nanjing General Hospital of Nanjing Military Command · CNNanjing Drum Tower Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: In this study, we used the TCGA database and ICGC database to establish a prognostic model of iron death associated with renal cell carcinoma, which can provide predictive value for the identification of iron death-related genes and clinical treatment of renal clear cell carcinoma. Methods: The gene expression profiles and clinical data of renal clear cell carcinoma and normal tissues were obtained in the TCGA database and ICGC database, and the differential genes related to iron death were screened out. The differential genes were screened out by single and multifactor Cox risk regression model. Results: Seven iron death differential genes (CLS2, FANCD2, PHKG2, ACSL3, ATP5MC3, CISD1, PEBP1) associated with renal clear cell carcinoma were finally screened and were refer to previous relevant studies. These genes are closely related to iron death and have great value for the prognosis of renal clear cell carcinoma. Conclusion: Seven iron death genes can accurately predict the survival of patients with renal clear cell carcinoma.

Indexed as

Carcinoma, Renal CellKidney NeoplasmsGene Expression Regulation, NeoplasticHumansIronPrognosisIron

Identifiers

PMID36081434
PMCPMC9448526
OpenAlexW4293860282

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.