Evidence map›Paper›PMID 36081431›Full record

ArticleComputational and mathematical methods in medicine2022

The Expression of miR-205 in Prostate Carcinoma and the Relationship with Prognosis in Patients.

Zhuifeng Guo, Xuwei Lu, Fan Yang, Liang Qin, Ning Yang, Peiran Cai, Conghui Han, Jiawen Wu, Hang Wang

RetractedOpen access · hybridAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Computational and mathematical methods in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Zhuifeng GuoDepartment of Urology, Minhang Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0003-0820-4748
Xuwei LuDepartment of Urology, Minhang Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0001-6550-0303
Fan YangDepartment of Urology, Minhang Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0002-2794-6459
Liang QinDepartment of Urology, Minhang Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0002-6422-9029
Ning YangDepartment of Urology, Minhang Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0002-7999-8306
Peiran CaiCenter for Traditional Chinese Medicine and Gut Microbiota, Minhang Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0003-1319-4222
Conghui HanDepartment of Urology, Xuzhou Central Hospital, Xuzhou, Jiangsu, China.ORCID https://orcid.org/0000-0002-8570-9195
Jiawen WuDepartment of Urology, Minhang Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0002-1691-9623
Hang WangDepartment of Urology, Zhongshan Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0002-3301-2548
Fudan University · CNSun Yat-sen University · CNXuzhou Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: We aimed to investigate the changes of serum and cell exosome miR-205 levels in patients with prostate carcinoma and its clinical significance. Materials and Methods: Firstly, pronouncement of miR-205 in normal and prostate carcinoma tissues was analyzed by using UALCAN database. The relationship between miR-205 in tumor tissues and the pathological and clinical characteristics of patients with prostate carcinoma were analyzed. Consequently, 60 people with prostate carcinoma were collected to the Minhang Hospital from August 2016 to August 2021. Serum of patients in the two groups was collected, and RNA in serum exosomes was extracted, and qRT-PCR was used to analyze the expression of miR-205 mediated by serum exosomes. Meanwhile, the relationship among the clinical as well as pathological aspects and bodement of patients with prostate carcinoma and the pronouncement level of miR-205 mediated by exosome was compared. Next, assays like wound healing and CKK-8 were used to investigate the effects of miR-205 in exosomes extracted from prostate carcinoma on the augmentation and metastasis of prostate carcinoma. Results: The results showed that the pronouncement level of miR-205 in tissues with prostate carcinoma was significantly lower than that in normal prostate tissues. In addition, the pronouncement level of miR-205 in fluid exosome of people with prostate carcinoma and exosomes derived from the lines of prostate carcinoma was considerably less than that in serum exosomes of healthy patients and that of normal cell lines of prostate. The pronouncement level of miR-205 in fluid exosomes of people with prostate carcinoma was negatively associated with cancer phase, uncontrolled cell division in lymph nodes, distant metastasis, and PSA level at initial diagnosis. Analysis (multivariate and univariate) showed that miR-205 pronouncement was a sovereign threat cause for prognosis of prostate cancer patients. Additionally, the pronouncement and metastasis of prostate carcinoma can be restricted by the overexpression of miR-205. Conclusion: The pronouncement of miR-205 in liquid derived exosomes is correlated with the prediction of people with prostate carcinoma and may be a new marker for identification and cure of prostate carcinoma.

Indexed as

CarcinomaMicroRNAsProstatic NeoplasmsGene Expression Regulation, NeoplasticHumansMalePrognosisProstateMicroRNAsMIR205, human

Identifiers

PMID36081431
PMCPMC9448532
OpenAlexW4293860193

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.