Evidence map›Paper›PMID 36081414›Full record

ArticleMultiple sclerosis journal - experimental, translational and clinical

Work difficulties in people with multiple sclerosis: The role of anxiety, depression and coping.

Eea van Egmond, K van der Hiele, Dam van Gorp, P J Jongen, Jjl van der Klink, M F Reneman, Eac Beenakker, Jjj van Eijk, Stfm Frequin, K de Gans and 7 more

Open access · goldAbstract read
In one paragraph

Article in Multiple sclerosis journal - experimental, translational and clinical. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Fatigue and depression influence the prevalence of anxiety in patients with multiple sclerosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Article
  6. Work Difficulties in People with Multiple Sclerosis.Journal of occupational rehabilitation · 2024
    Article
  7. Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 12 institutions in 2 countries.

Eea van EgmondDepartment of Neurology, Elisabeth-TweeSteden Hospital, Tilburg, the Netherlands.ORCID https://orcid.org/0000-0003-2089-303X
K van der HieleInstitute of Psychology, Health, Medical and Neuropsychology Unit, Leiden University, Leiden, the Netherlands.
Dam van GorpDepartment of Care Ethics, University of Humanistic Studies, Utrecht, the Netherlands.
P J JongenMS4 Research Institute, Nijmegen, the Netherlands.ORCID https://orcid.org/0000-0002-9202-6309
Jjl van der KlinkTilburg School of Social and Behavioural Sciences, Tranzo Scientific Centre for Care and Welfare, Tilburg University, Tilburg, the Netherlands.
M F RenemanDepartment of Rehabilitation Medicine, Centre for Rehabilitation, University of Groningen, University Medical Centre Groningen, Haren, the Netherlands.
Eac BeenakkerDepartment of Neurology, Medical Centre Leeuwarden, Leeuwarden, the Netherlands.
Jjj van EijkDepartment of Neurology, Jeroen Bosch Hospital, 's-Hertogenbosch, the Netherlands.
Stfm FrequinDepartment of Neurology, St Antonius Hospital, Nieuwegein, the Netherlands.
K de GansDepartment of Neurology, Groene Hart Hospital, the Netherlands.
B M van GeelDepartment of Neurology, NoordWest Ziekenhuisgroep, the Netherlands.
Ohh GerlachDepartment of Neurology, Zuyderland Medical Centre, Sittard-Geleen, the Netherlands.
Gjd HengstmanUpendo MS Clinic, Boxtel, the Netherlands.
J P MostertDepartment of Neurology, Rijnstate Hospital, the Netherlands.
Wim VerhagenDepartment of Neurology, Canisius-Wilhelmina Hospital, Nijmegen, the Netherlands.
Ham MiddelkoopInstitute of Psychology, Health, Medical and Neuropsychology Unit, Leiden University, Leiden, the Netherlands.
L H VisserDepartment of Neurology, Elisabeth-TweeSteden Hospital, Tilburg, the Netherlands.
Leiden University · NLUniversity Medical Center Groningen · NLUniversity of Humanistic Studies · NLCanisius-Wilhelmina Ziekenhuis · NLGroene Hart Ziekenhuis · NLJeroen Bosch Ziekenhuis · NLMaastricht University Medical Centre · NLMedisch Centrum Leeuwarden · NLNoordwest Ziekenhuisgroep · NLRijnstate Hospital · NLSt. Antonius Ziekenhuis · NLUniversity of South Africa · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Symptoms of anxiety and depression affect the daily life of people with multiple sclerosis (MS). This study examined work difficulties and their relationship with anxiety, depression and coping style in people with MS. Methods: 219 employed people with MS (median age  =  43 years, 79% female) completed questionnaires on anxiety, depression, coping style, demographics and work difficulties, and underwent a neurological examination. Two regression analyses were performed with work difficulties as the dependent variable and either anxiety or depression as continuous independent variables. Coping style, age, gender, educational level, MS-related disability and disease duration were added as additional predictors, as well as interaction terms between coping style and either symptoms of depression or anxiety. Results: A significant model was found ( Conclusions: Work difficulties were positively related to anxiety, depression, emotion- and avoidance-oriented coping and MS-related disability in workers with MS.

Indexed as

anxietycoping behaviourdepressionemploymentmultiple sclerosiswork

Identifiers

PMID36081414
PMCPMC9445483
OpenAlexW4294584289

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.