ArticleBiophysical journal2022
Geometric effects in gas vesicle buckling under ultrasound.
Article in Biophysical journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Cavitation behaviors of genetically engineered bacterial protein nanoparticles induced by pulsed ultrasound.Ultrasonics sonochemistry · 2026Article
- Focused Ultrasound-Triggered Burst Release and Enrichment of Engineered Bacteria for Tumor Therapy.Biomaterials research · 2026Article
- Multiplexed ultrasound imaging of gene expression.Nature methods · 2025Article
- Dissipative Particle Dynamics Models of Encapsulated Microbubbles and Nanoscale Gas Vesicles for Biomedical Ultrasound Simulations.ACS applied nano materials · 2025Article
- Achieving single cell acoustic localisation with deactivation super resolution.NPJ acoustics · 2025Article
- Directed Evolution of Acoustic Reporter Genes Using High-Throughput Acoustic Screening.ACS synthetic biology · 2024Article
- Protein Gas Vesicles ofACS nano · 2024Article
- Truly Tiny Acoustic Biomolecules for Ultrasound Imaging and Therapy.Advanced materials (Deerfield Beach, Fla.) · 2024Article
- Truly tiny acoustic biomolecules for ultrasound imaging and therapy.bioRxiv : the preprint server for biology · 2023Article
- Structure of Anabaena flos-aquae gas vesicles revealed by cryo-ET.Structure (London, England : 1993) · 2023Article
- Bacterial flotation devices enhance ultrasound imaging.Biophysical journal · 2022Article
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Authors and funding
10 authors.
Funding
Abstract
Acoustic reporter genes based on gas vesicles (GVs) have enabled the use of ultrasound to noninvasively visualize cellular function in vivo. The specific detection of GV signals relative to background acoustic scattering in tissues is facilitated by nonlinear ultrasound imaging techniques taking advantage of the sonomechanical buckling of GVs. However, the effect of geometry on the buckling behavior of GVs under exposure to ultrasound has not been studied. To understand such geometric effects, we developed computational models of GVs of various lengths and diameters and used finite element simulations to predict their threshold buckling pressures and postbuckling deformations. We demonstrated that the GV diameter has an inverse cubic relation to the threshold buckling pressure, whereas length has no substantial effect. To complement these simulations, we experimentally probed the effect of geometry on the mechanical properties of GVs and the corresponding nonlinear ultrasound signals. The results of these experiments corroborate our computational predictions. This study provides fundamental insights into how geometry affects the sonomechanical properties of GVs, which, in turn, can inform further engineering of these nanostructures for high-contrast, nonlinear ultrasound imaging.
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