Evidence map›Paper›PMID 36081283›Full record

ReviewEBioMedicine2022

Pre-clinical models to study abnormal uterine bleeding (AUB).

Aleksandra O Tsolova, Rocío Martínez Aguilar, Jacqueline A Maybin, Hilary O D Critchley

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in EBioMedicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. [Estrogen, estrogen receptor and miR-21 in adenomyosis: their pathogenic roles and regulatory interactions].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Aleksandra O TsolovaMRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK.
Rocío Martínez AguilarMRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK.
Jacqueline A MaybinMRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK.
Hilary O D CritchleyMRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK. Electronic address: hilary.critchley@ed.ac.uk.

Funding

Medical Research Council MR/N022556/1
6 · The paper itself

Abstract

Abnormal Uterine Bleeding (AUB) is a common debilitating condition that significantly reduces quality of life of women across the reproductive age span. AUB creates significant morbidity, medical, social, and economic problems for women, their families, workplace, and health services. Despite the profoundly negative effects of AUB on public health, advancement in understanding the pathophysiology of AUB and the discovery of novel effective therapies is slow due to lack of reliable pre-clinical models. This review discusses currently available laboratory-based pre-clinical scientific models and how they are used to study AUB. Human and animal in vitro, ex vivo, and in vivo models will be described along with advantages and limitations of each method.

Indexed as

Quality of LifeUterine HemorrhageFemaleHumansAbnormal uterine bleeding (AUB)AdenomyosisEndometrial co-culturesEndometriumEpithelial organoidsLeiomyoma (uterine fibroids)Pre-clinical models

Identifiers

PMID36081283
PMCPMC9465267

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.