Evidence map›Paper›PMID 36080642›Full record

ArticlePolymers2022

Shall We Tune? From Core-Shell to Cloud Type Nanostructures in Heparin/Silica Hybrids.

Giulio Pota, Giuseppe Vitiello, Virginia Venezia, Francesca Della Sala, Assunta Borzacchiello, Aniello Costantini, Luigi Paduano, Leide P Cavalcanti, Fabiana Tescione, Brigida Silvestri and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Polymers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Giulio PotaDepartment of Chemical, Materials and Production Engineering, University of Naples Federico II, Piazzale Tecchio 80, 80125 Naples, Italy.ORCID 0000-0002-3949-7232
Giuseppe VitielloDepartment of Chemical, Materials and Production Engineering, University of Naples Federico II, Piazzale Tecchio 80, 80125 Naples, Italy.ORCID 0000-0003-3389-6942
Virginia VeneziaDepartment of Chemical, Materials and Production Engineering, University of Naples Federico II, Piazzale Tecchio 80, 80125 Naples, Italy.ORCID 0000-0002-6368-2681
Francesca Della SalaInstitute of Polymers, Composites and Biomaterials, National Research Council, (IPCB-CNR), 80125 Naples, Italy.ORCID 0000-0001-7041-4565
Assunta BorzacchielloInstitute of Polymers, Composites and Biomaterials, National Research Council, (IPCB-CNR), 80125 Naples, Italy.
Aniello CostantiniDepartment of Chemical, Materials and Production Engineering, University of Naples Federico II, Piazzale Tecchio 80, 80125 Naples, Italy.
Luigi PaduanoDepartment of Chemical Sciences, University of Naples Federico II, Via Cinthia, 80126 Naples, Italy.
Leide P CavalcantiISIS Neutron Source, STFC, Didcot OX11 0QX, UK.ORCID 0000-0002-0408-0058
Fabiana TescioneInstitute of Polymers, Composites and Biomaterials, National Research Council, (IPCB-CNR), 80125 Naples, Italy.ORCID 0000-0001-7027-294X
Brigida SilvestriDepartment of Civil, Architectural and Environmental Engineering, University of Naples Federico II, Via Claudio 21, 80125 Naples, Italy.ORCID 0000-0003-1654-8698
Giuseppina LucianiDepartment of Chemical, Materials and Production Engineering, University of Naples Federico II, Piazzale Tecchio 80, 80125 Naples, Italy.ORCID 0000-0002-1169-0137

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heparin plays multiple biological roles depending on the availability of active sites strongly influenced by the conformation and the structure of polysaccharide chains. Combining different components at the molecular scale offers an extraordinary chance to easily tune the structural organization of heparin required for exploring new potential applications. In fact, the combination of different material types leads to challenges that cannot be achieved by each single component. In this study, hybrid heparin/silica nanoparticles were synthesized, and the role of silica as a templating agent for heparin supramolecular organization was investigated. The effect of synthesis parameters on particles compositions was deeply investigated by Fourier Transform Infrared Spectroscopy (FTIR) and Thermogravimetric Analysis (TGA). Transmission Electron Microscopy (TEM) reveals a different supramolecular organization of both components, leading to amazing organic-inorganic nanoparticles with different behavior in drug encapsulation and release. Furthermore, favorable biocompatibility for healthy human dermal fibroblasts (HDF) and tumor HS578T cells has been assessed, and a different biological behavior was observed, ascribed to different surface charge and morphology of synthesized nanoparticles.

Indexed as

biocompatibilitydrug releaseheparinhybrid nanoparticlesSiO2sol-gel synthesis

Identifiers

PMID36080642
PMCPMC9460005

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.