Evidence map›Paper›PMID 36080515›Full record

ReviewPolymers2022

Hyaluronic Acid: A Review of the Drug Delivery Capabilities of This Naturally Occurring Polysaccharide.

Ciara Buckley, Emma J Murphy, Therese R Montgomery, Ian Major

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Polymers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
11.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 112 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Ciara BuckleyPRISM Research Institute, Technological University of the Shannon, N37 HD68 Athlone, Ireland.ORCID 0000-0001-9843-340X
Emma J MurphyPRISM Research Institute, Technological University of the Shannon, N37 HD68 Athlone, Ireland.ORCID 0000-0002-5620-0058
Therese R MontgomerySchool of Science and Computing, Atlantic Technological University, H91 T8NW Galway, Ireland.
Ian MajorPRISM Research Institute, Technological University of the Shannon, N37 HD68 Athlone, Ireland.ORCID 0000-0002-0538-9786
Shannon Applied Biotechnology Centre · IETechnological University Dublin · IE

Funding

Irish Research Council GOIPG/2020/797
6 · The paper itself

Abstract

The inclusion of physiologically active molecules into a naturally occurring polymer matrix can improve the degradation, absorption, and release profile of the drug, thus boosting the therapeutic impact and potentially even reducing the frequency of administration. The human body produces significant amounts of polysaccharide hyaluronic acid, which boasts exceptional biocompatibility, biodegradability, and one-of-a-kind physicochemical features. In this review, we will examine the clinical trials currently utilizing hyaluronic acid and address the bright future of this versatile polymer, as well as summarize the numerous applications of hyaluronic acid in drug delivery and immunomodulation.

Indexed as

bioactivesdrug-deliveryheteropolysaccharidesimmunotherapiesnaturally-occurring polymerspolysaccharide

Identifiers

PMID36080515
PMCPMC9460006
OpenAlexW4292878358

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.