Evidence map›Paper›PMID 36080493›Full record

ReviewMolecules (Basel, Switzerland)2022

Prostate Cancer Review: Genetics, Diagnosis, Treatment Options, and Alternative Approaches.

Mamello Sekhoacha, Keamogetswe Riet, Paballo Motloung, Lemohang Gumenku, Ayodeji Adegoke, Samson Mashele

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 497 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
497citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

497 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Pooled it
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  4. Efficacy of [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Pooled it
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  9. Article
  10. Article
  11. Article
  12. Review
  13. Recent advances in hormone-based biopharmaceuticals for cancer therapy.Journal of the Egyptian National Cancer Institute · 2026
    Review
  14. Article
  15. Article
  16. Article
  17. Ultrasound-Guided Transperineal Versus Transrectal Prostate Aspiration Biopsy in Diagnosing Prostate Cancer: An Observational Comparison Study.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2026
    Observational
  18. Article
  19. Review
  20. Article

437 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mamello SekhoachaDepartment of Pharmacology, University of the Free State, Bloemfontein 9300, South Africa.
Keamogetswe RietDepartment of Health Sciences, Central University of Technology, Bloemfontein 9300, South Africa.
Paballo MotloungDepartment of Health Sciences, Central University of Technology, Bloemfontein 9300, South Africa.
Lemohang GumenkuDepartment of Health Sciences, Central University of Technology, Bloemfontein 9300, South Africa.
Ayodeji AdegokeDepartment of Pharmacology, University of the Free State, Bloemfontein 9300, South Africa.ORCID 0000-0002-9968-8014
Samson MasheleDepartment of Health Sciences, Central University of Technology, Bloemfontein 9300, South Africa.

Funding

National Research Foundation 129891
6 · The paper itself

Abstract

Prostate cancer is one of the malignancies that affects men and significantly contributes to increased mortality rates in men globally. Patients affected with prostate cancer present with either a localized or advanced disease. In this review, we aim to provide a holistic overview of prostate cancer, including the diagnosis of the disease, mutations leading to the onset and progression of the disease, and treatment options. Prostate cancer diagnoses include a digital rectal examination, prostate-specific antigen analysis, and prostate biopsies. Mutations in certain genes are linked to the onset, progression, and metastasis of the cancer. Treatment for localized prostate cancer encompasses active surveillance, ablative radiotherapy, and radical prostatectomy. Men who relapse or present metastatic prostate cancer receive androgen deprivation therapy (ADT), salvage radiotherapy, and chemotherapy. Currently, available treatment options are more effective when used as combination therapy; however, despite available treatment options, prostate cancer remains to be incurable. There has been ongoing research on finding and identifying other treatment approaches such as the use of traditional medicine, the application of nanotechnologies, and gene therapy to combat prostate cancer, drug resistance, as well as to reduce the adverse effects that come with current treatment options. In this article, we summarize the genes involved in prostate cancer, available treatment options, and current research on alternative treatment options.

Indexed as

Prostatic NeoplasmsAndrogen AntagonistsHumansMaleNeoplasm Recurrence, LocalProstatectomyProstate-Specific AntigenSalvage TherapyAndrogen AntagonistsProstate-Specific Antigengene therapygenetics of prostate cancerprostate cancerprostate cancer diagnosisprostate-specific antigen (PSA)traditional medicine

Identifiers

PMID36080493
PMCPMC9457814

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.