Evidence map›Paper›PMID 36080463›Full record

ArticleMolecules (Basel, Switzerland)2022

Hemocompatibile Thin Films Assessed under Blood Flow Shear Forces.

Roman Major, Grażyna Wilczek, Justyna Więcek, Maciej Gawlikowski, Hanna Plutecka, Katarzyna Kasperkiewicz, Marcin Kot, Małgorzata Pomorska, Roman Ostrowski, Magdalena Kopernik

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Simulation and Modeling of the Adhesion ofPathogens (Basel, Switzerland) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Roman MajorInstitute of Metallurgy and Materials Science, Polish Academy of Sciences, 25 Reymonta St., 30-059 Cracow, Poland.ORCID 0000-0003-3809-1908
Grażyna WilczekInstitute of Biology, Biotechnology and Environmental Protection, University of Silesia, Bankowa St. 9, 40-007 Katowice, Poland.ORCID 0000-0002-3276-0333
Justyna WięcekInstitute of Metallurgy and Materials Science, Polish Academy of Sciences, 25 Reymonta St., 30-059 Cracow, Poland.ORCID 0000-0002-2053-8874
Maciej GawlikowskiFaculty of Biomedical Engineering, Department of Biosensors and Processing of Biomedical Signals, Silesian University of Technology, Roosevelt St. 40, 41-800 Zabrze, Poland.ORCID 0000-0002-6526-2656
Hanna PluteckaDivision of Molecular Biology and Clinical Genetics, Faculty of Medicine, Jagiellonian University Medical College, Skawinska St. 8, 31-066 Cracow, Poland.
Katarzyna KasperkiewiczInstitute of Biology, Biotechnology and Environmental Protection, Faculty of Natural Sciences, University of Silesia in Katowice, Jagiellońska St., 2840-032 Katowice, Poland.ORCID 0000-0002-9851-790X
Marcin KotFaculty of Mechanical Engineering and Robotics, AGH University of Science and Technology, Al. Mickiewicza 30, 30-059 Cracow, Poland.
Małgorzata PomorskaInstitute of Metallurgy and Materials Science, Polish Academy of Sciences, 25 Reymonta St., 30-059 Cracow, Poland.
Roman OstrowskiInstitute of Optoelectronics, Military University of Technology, Gen. S. Kaliskiego St. 2, 00-908 Warsaw, Poland.
Magdalena KopernikFaculty of Metals Engineering and Industrial Computer Science, AGH University of Science and Technology, Al. Mickiewicza 30, 30-059 Cracow, Poland.ORCID 0000-0001-8705-6506
Institute of Metallurgy and Materials Science · PLAGH University of Krakow · PLUniversity of Silesia in Katowice · PLJagiellonian University · PLMilitary University of Technology in Warsaw · PLSilesian University of Technology · PL

Funding

Military University of Technology in Warsaw UGB/22-723/2022/WATNational Centre for Research and Development M-ERA. NET/2014/01/2016
6 · The paper itself

Abstract

The aim of this study was to minimize the risk of life-threatening thromboembolism in the ventricle through the use of a new biomimetic heart valve based on metal-polymer composites. Finite volume element simulations of blood adhesion to the material were carried out, encompassing radial flow and the cone and plane test together with determination of the effect of boundary conditions. Both tilt-disc and bicuspid valves do not have optimized blood flow due to their design based on rigid valve materials (leaflet made of pyrolytic carbon). The main objective was the development of materials with specific properties dedicated to contact with blood. Materials were evaluated by dynamic tests using blood, concentrates, and whole human blood. Hemostability tests under hydrodynamic conditions were related to the mechanical properties of thin-film materials obtained from tribological tests. The quality of the coatings was high enough to avoid damage to the coating even as they were exposed up to maximum loading. Analysis towards blood concentrates of the hydrogenated carbon sample and the nitrogen-doped hydrogenated carbon sample revealed that the interaction of the coating with erythrocytes was the strongest. Hemocompatibility evaluation under hydrodynamic conditions confirmed very good properties of the developed coatings.

Indexed as

Heart Valve ProsthesisCarbonHumansHydrodynamicsNitrogenCarbonNitrogenblood–material interactionblood shear stressheart valvehemocompatibilityImpact-Rnanoindentationradial flow chamberthin coatings

Identifiers

PMID36080463
PMCPMC9458224
OpenAlexW4295080656

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.