Evidence map›Paper›PMID 36080375›Full record

ArticleMolecules (Basel, Switzerland)2022

Structural Elucidation of Alkali Degradation Impurities of Favipiravir from the Oral Suspension: UPLC-TQ-ESI-MS/MS and NMR.

Ravi Patel, Abhishek Dube, Ravisinh Solanki, Dignesh Khunt, Shalin Parikh, Vijayabhaskarreddy Junnuthula, Sathish Dyawanapelly

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 19 citations in OpenAlex.

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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Ravi PatelGraduate School of Pharmacy, Gujarat Technological University, Gandhinagar 382028, Gujarat, India.ORCID 0000-0002-7453-0122
Abhishek DubeGraduate School of Pharmacy, Gujarat Technological University, Gandhinagar 382028, Gujarat, India.
Ravisinh SolankiGraduate School of Pharmacy, Gujarat Technological University, Gandhinagar 382028, Gujarat, India.ORCID 0000-0003-2977-554X
Dignesh KhuntGraduate School of Pharmacy, Gujarat Technological University, Gandhinagar 382028, Gujarat, India.ORCID 0000-0002-8850-7468
Shalin ParikhSenores Pharmaceuticals Pvt. Ltd., Ahmedabad 380058, Gujarat, India.ORCID 0000-0003-3369-753X
Vijayabhaskarreddy JunnuthulaDrug Research Program, Faculty of Pharmacy, University of Helsinki, Viikinkaari 5 E, 00790 Helsinki, Finland.
Sathish DyawanapellyDepartment of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai 400019, Maharashtra, India.ORCID 0000-0002-2310-1651
Gujarat Technological University · INInstitute of Chemical Technology · INIntas Pharmaceuticals (India) · INUniversity of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A novel stability-indicating, reversed-phase, high-performance liquid chromatography (RP-HPLC) method was developed and validated for the determination of favipiravir in an oral suspension. The effective separation of favipiravir and its degradation products was achieved on a Zorbax Eclipse Plus C18 column (5 μm particle size, 150 mm length × 4.6 mm diameter). The mobile phase was prepared by mixing 5 mM of phosphate buffer (pH 3.5) and methanol in a 75:25

Indexed as

AlkaliesTandem Mass SpectrometryAmidesChromatography, High Pressure LiquidPyrazinesSuspensionsAlkaliesAmidesfavipiravirPyrazinesSuspensionscharacterizationCOVID-19degradation productsfavipiravirRP-HPLCstability indicatingUPLC-MS/MS

Identifiers

PMID36080375
PMCPMC9457609
OpenAlexW4294292762

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.