Evidence map›Paper›PMID 36080174›Full record

ArticleMolecules (Basel, Switzerland)2022

Synthesis, Structure and Antileishmanial Evaluation of Endoperoxide-Pyrazole Hybrids.

Patrícia S M Amado, Inês C C Costa, José A Paixão, Ricardo F Mendes, Sofia Cortes, Maria L S Cristiano

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Patrícia S M AmadoCenter of Marine Sciences, CCMAR, Gambelas Campus, University of Algarve, UAlg, 8005-139 Faro, Portugal.ORCID 0000-0002-7307-9210
Inês C C CostaCenter of Marine Sciences, CCMAR, Gambelas Campus, University of Algarve, UAlg, 8005-139 Faro, Portugal.ORCID 0000-0003-2711-5441
José A PaixãoCFisUC, Department of Physics, University of Coimbra, 3004-516 Coimbra, Portugal.ORCID 0000-0003-4634-7395
Ricardo F MendesCICECO-Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, Portugal.ORCID 0000-0001-8242-324X
Sofia CortesGlobal Health and Tropical Medicine-GHTM, Instituto de Higiene e Medicina Tropical-IHMT, Universidade Nova de Lisboa-NOVA, 1349-008 Lisboa, Portugal.ORCID 0000-0001-5850-6950
Maria L S CristianoCenter of Marine Sciences, CCMAR, Gambelas Campus, University of Algarve, UAlg, 8005-139 Faro, Portugal.ORCID 0000-0002-9447-2855
University of Algarve · PTUniversidade Nova de Lisboa · PTUniversity of Aveiro · PTUniversity of Coimbra · PT

Funding

CRESC Algarve 2020 and COMPETE 2020 EMBRC.PT ALG-01-0145-FEDER-022121Fundação para a Ciência e Tecnologia IF/00743/2015/CP1320, UID/Multi/04413/2019 (GHTM)Fundação para a Ciência e Tecnologia SFRH/BD/130407/2017 and COVID/BD/152392/2022 (P.S.M.A.), SFRH/BD/08242/2020 (I.C.C.C.), CEECIND/00553/2017 (R.F.M.)Fundação para a Ciência e Tecnologia UIDB/04326/2020, UIDP/04326/2020, LA/P/0101/2020 (CCMar)Fundação para a Ciência e Tecnologia UIDB/04564/2021, UIDP/04564/2021 (CFisUC)Fundação para a Ciência e Tecnologia UIDB/50011/2020, UIDP/50011/2020 (CQC) & LA/P/0006/2020 (IMS)
6 · The paper itself

Abstract

Leishmaniases are among the most impacting neglected tropical diseases. In attempts to repurpose antimalarial drugs or candidates, it was found that selected 1,2,4-trioxanes, 1,2,4,5-tetraoxanes, and pyrazole-containing chemotypes demonstrated activity against

Indexed as

Antiprotozoal AgentsLeishmaniaLeishmania infantumLeishmaniasisTetraoxanesHumansPyrazolesAntiprotozoal AgentsPyrazolesTetraoxanes1,2,4,5-tetraoxanes1,2,4-trioxanesantileishmanial chemotherapyendoperoxide–pyrazole hybridsprototropic tautomerismpyrazoles

Identifiers

PMID36080174
PMCPMC9457810
OpenAlexW4293221205

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.