ReviewMolecules (Basel, Switzerland)2022
Bridging a Century-Old Problem: The Pathophysiology and Molecular Mechanisms of HA Filler-Induced Vascular Occlusion (FIVO)-Implications for Therapeutic Interventions.
Review in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Guide for Managing Vascular Occlusion Caused by Fillers with Exclusive Cutaneous Involvement: A Review of Diagnosis, Classification, and Treatment.Aesthetic plastic surgery · 2026Pooled it
- Arterial Embolism After Facial Fat Grafting: A Systematic Literature Review.Aesthetic plastic surgery · 2023Pooled it
- Guide for Managing Vascular Occlusion Due to Fillers with Extended Neuro-Ophthalmic Involvement: A Review of Diagnosis, Classification and Treatment.Aesthetic plastic surgery · 2026Review
- Doppler Ultrasound Findings in Filler-Related Facial Vascular Adverse Events: An International Multicenter Study.Diagnostics (Basel, Switzerland) · 2026Article
- Hyaluronic Acid Dermal Filler-Associated Vascular Occlusion-A Review of Prevention and Management Strategies.Journal of cosmetic dermatology · 2026Review
- Hyperbaric Oxygen Therapy in the Management of Dermal Filler-Induced Vascular Occlusion: A Scoping Review.The Journal of clinical and aesthetic dermatology · 2026Review
- Pilot Study: Hyaluronic Acid Fillers in the Management of Scars After Skin Cancer Surgery.Plastic and reconstructive surgery. Global open · 2026Article
- Managing Nasal Ischemia and Necrosis Post-Triamcinolone Injection: A New Case Series.Case reports in otolaryngology · 2026Article
- Advances in Anti-aging Procedures: A Comprehensive Review of Surgical and Non-surgical Rejuvenation Techniques.Cureus · 2025Review
- Permanent Vision Loss Due to Vascular Variation After Ear Hyaluronic Acid Injection: Two Case Reports and Literature Reviews.Aesthetic plastic surgery · 2025Review
- Essential Pharmaceutical Drugs in the Filler Emergency Kit.Aesthetic plastic surgery · 2025Review
- Vascular Embolism After Dull Needle Injection of Hyaluronic Acid Into Glabellar Wrinkles in Preformed Subdermal Tunnels: A Case Report and Review of the Literature.Journal of cosmetic dermatology · 2025Review
- Arterioembolic Characteristics of Differentially Diluted CaHA-CMC Gels Within An Artificial Macrovascular Perfusion Model.Aesthetic surgery journal · 2025Article
- Retrobulbar Hyaluronidase in Hyaluronic Acid-Induced Ocular Vascular Occlusion: Efficacy, Challenges, and Implications for Clinical Practice.Aesthetic plastic surgery · 2025Review
- A new protocol (THIS and FAT) for the treatment of filler-induced vascular occlusion: a case series.Frontiers in medicine · 2025Article
- Bond-Centric Modifications of Hyaluronic Acid: Synthesis, Processing, and Biomedical Applications.International journal of nanomedicine · 2025Review
- Might Topical Heparin Help With Occlusion Emergencies After Accidental Intra-Arterial Hyaluronic Acid Injections?Aesthetic surgery journal. Open forum · 2025Article
- Localization and Staging of Vascular Adverse Events After Facial Fillers: A Detailed Assessment.Aesthetic surgery journal. Open forum · 2025Article
- Correction: Soares, D.J. Bridging a Century-Old Problem: The Pathophysiology and Molecular Mechanisms of HA Filler-Induced Vascular Occlusion (FIVO)-Implications for Therapeutic Interventions.Molecules (Basel, Switzerland) · 2024Article
- Partially Reversible Episode of Blindness after Intravascular Hyaluronic Acid Filler Injection.Plastic and reconstructive surgery. Global open · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biocompatible hyaluronic acid (HA, hyaluronan) gel implants have altered the therapeutic landscape of surgery and medicine, fostering an array of innovative products that include viscosurgical aids, synovial supplements, and drug-eluting nanomaterials. However, it is perhaps the explosive growth in the cosmetic applications of injectable dermal fillers that has captured the brightest spotlight, emerging as the dominant modality in plastic surgery and aesthetic medicine. The popularity surge with which injectable HA fillers have risen to
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.