Evidence map›Paper›PMID 36080127›Full record

ArticleMolecules (Basel, Switzerland)2022

Design, Synthesis, and Evaluation of New Mesenchymal-Epithelial Transition Factor (c-Met) Kinase Inhibitors with Dual Chiral Centers.

Han Yao, Yuanyuan Ren, Jun Yan, Jiadai Liu, Jinhui Hu, Ming Yan, Xingshu Li

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Han YaoSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.ORCID 0000-0002-4441-0445
Yuanyuan RenSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Jun YanSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.ORCID 0000-0003-1552-8003
Jiadai LiuSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Jinhui HuSchool of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, China.ORCID 0000-0001-7924-1656
Ming YanSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.ORCID 0000-0001-9888-0744
Xingshu LiSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Sun Yat-sen University · CNWuyi University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of tepotinib derivatives with two chiral centers was designed, synthesized, and evaluated as anticancer agents. The optimal compound

Indexed as

Antineoplastic AgentsApoptosisCell Cycle CheckpointsCell ProliferationDrug DesignDrug Screening Assays, AntitumorMolecular StructureProtein Kinase InhibitorsStructure-Activity RelationshipAntineoplastic AgentsProtein Kinase Inhibitorscancerchiral compoundsc-Met inhibitorskinasetepotinib

Identifiers

PMID36080127
PMCPMC9457593
OpenAlexW4292860332

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.