ArticleNutrients2022
Comparative Proteomic Analysis of Proteins in Breast Milk during Different Lactation Periods.
Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Determinants of early interruption of exclusive breastfeeding: a qualitative meta-synthesis.BMC public health · 2026Pooled it
- Dynamic Remodeling of the Human Milk Serum Proteome Across Lactation: A Paired Two-Stage DIA Proteomic Study in Term and Preterm Mothers.Nutrients · 2026Article
- Time-Dependent Differences in the Human Milk Proteome After Preterm Birth: A Paired Two-Stage Proteomic Study.Nutrients · 2026Article
- Global protein profiling of human milk using pre-enriched RNA-sequence libraries.Scientific reports · 2026Article
- Breast Milk Proteome: Changes in the Different Stages of Lactation and Impacts of Gestational Diabetes Mellitus and Body Mass Index.Molecular nutrition & food research · 2025Article
- Article
- [Mammary epithelial cells from women synthetize omega-3 and 6 fatty acids].Revista medica del Instituto Mexicano del Seguro Social · 2025Observational
- Multi-omics analysis reveals alterations of breastmilk metabolites and proteins in Hong Kong lactating mothers.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- Review
- Science and Faith to Understand Milk Bioactivity for Infants.Nutrients · 2024Review
- Article
- Skin to Skin Contact Correlated with Improved Production and Consumption of Mother's Own Milk.Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine · 2023Article
- Mechanisms of Maternal Diet-Induced Obesity Affecting the Offspring Brain and Development of Affective Disorders.Metabolites · 2023Review
- Milk Fat Globules: 2024 Updates.Newborn (Clarksville, Md.)Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Breast milk is an unparalleled food for infants, as it can meet almost all of their nutritional needs. Breast milk in the first month is an important source of acquired immunity. However, breast milk protein may vary with the stage of lactation. Therefore, the aim of this study was to use a data-independent acquisition approach to determine the differences in the proteins of breast milk during different lactation periods. The study samples were colostrum (3-6 days), transitional milk (7-14 days), and mature milk (15-29 days). The results identified a total of 2085 different proteins, and colostrum contained the most characteristic proteins. Protein expression was affected by the lactation stage. The proteins expressed in breast milk changed greatly between day 3 and day 14 and gradually stabilized after 14 days. The expression levels of lactoferrin, immunoglobulin, and clusterin were the highest in colostrum. CTP synthase 1, C-type lectin domain family 19 member A, secretoglobin family 3A member 2, trefoil factor 3 (TFF3), and tenascin were also the highest in colostrum. This study provides further insights into the protein composition of breast milk and the necessary support for the design and production of infant formula.
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Registered trials
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