Evidence map›Paper›PMID 36079744›Full record

ArticleNutrients2022

Effect of 24-Week, Late-Evening Ingestion of a Calcium-Fortified, Milk-Based Protein Matrix on Biomarkers of Bone Metabolism and Site-Specific Bone Mineral Density in Postmenopausal Women with Osteopenia.

Catherine Norton, Manjula Hettiarachchi, Rachel Cooke, Marta Kozior, Hilkka Kontro, Rosemary Daniel, Philip Jakeman

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Catherine NortonHealth Research Institute and Department of Physical Education and Sport Sciences, University of Limerick, V94 T9PX Limerick, Ireland.ORCID 0000-0001-8973-6759
Manjula HettiarachchiHealth Research Institute and Department of Physical Education and Sport Sciences, University of Limerick, V94 T9PX Limerick, Ireland.ORCID 0000-0003-1203-1368
Rachel CookeHealth Research Institute and Department of Physical Education and Sport Sciences, University of Limerick, V94 T9PX Limerick, Ireland.
Marta KoziorHealth Research Institute and Department of Physical Education and Sport Sciences, University of Limerick, V94 T9PX Limerick, Ireland.ORCID 0000-0003-0945-7560
Hilkka KontroHealth Research Institute and Department of Physical Education and Sport Sciences, University of Limerick, V94 T9PX Limerick, Ireland.
Rosemary DanielHealth Research Institute and Department of Physical Education and Sport Sciences, University of Limerick, V94 T9PX Limerick, Ireland.
Philip JakemanHealth Research Institute and Department of Physical Education and Sport Sciences, University of Limerick, V94 T9PX Limerick, Ireland.ORCID 0000-0002-1199-080X
University of Limerick · IE

Funding

Enterprise Ireland IP/2016/ 0476
6 · The paper itself

Abstract

Dietary calcium intake is a modifiable, lifestyle factor that can affect bone health and the risk of fracture. The diurnal rhythm of bone remodelling suggests nocturnal dietary intervention to be most effective. This study investigated the effect of daily, bed-time ingestion of a calcium-fortified, milk-derived protein matrix (MBPM) or control (CON), for 24 weeks, on serum biomarkers of bone resorption (C-terminal telopeptide of type I collagen, CTX) and formation (serum pro-collagen type 1 N-terminal propeptide, P1NP), and site-specific aerial bone mineral density (BMD), trabecular bone score (TBS), in postmenopausal women with osteopenia. The MBPM supplement increased mean daily energy, protein, and calcium intake, by 11, 30, and 107%, respectively. 24-week supplementation with MBPM decreased CTX by 23%, from 0.547 (0.107) to 0.416 (0.087) ng/mL (p < 0.001) and P1NP by 17%, from 60.6 (9.1) to 49.7 (7.2) μg/L (p < 0.001). Compared to CON, MBPM induced a significantly greater reduction in serum CTX (mean (CI95%); −9 (8.6) vs. −23 (8.5)%, p = 0.025 but not P1NP −19 (8.8) vs. −17 (5.2)%, p = 0.802). No significant change in TBS, AP spine or dual femur aerial BMD was observed for CON or MBPM. This study demonstrates the potential benefit of bed-time ingestion of a calcium-fortified, milk-based protein matrix on homeostatic bone remodelling but no resultant treatment effect on site-specific BMD in postmenopausal women with osteopenia.

Indexed as

Bone Diseases, MetabolicOsteoporosis, PostmenopausalAnimalsBiomarkersBone DensityBone RemodelingCalciumCalcium, DietaryCollagen Type IEatingFemaleHumansMilkMilk ProteinsPostmenopauseBiomarkersCalciumCalcium, DietaryCollagen Type IMilk Proteinsbone healthbone remodellingbone turnover markersmilk protein matrixnutrient interventionnutrient timingosteopeniapostmenopausal womenrandomized control trial

Identifiers

PMID36079744
PMCPMC9460355
OpenAlexW4293220707

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.