Evidence map›Paper›PMID 36078994›Full record

ArticleJournal of clinical medicine2022

Primary Staging of Prostate Cancer Patients with [

Manuela A Hoffmann, Jonas Müller-Hübenthal, Florian Rosar, Nicolas Fischer, Finn Edler von Eyben, Hans-Georg Buchholz, Helmut J Wieler, Mathias Schreckenberger

2 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07386496 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

The Role of 18F-PSMA PET in Prostate Cancer Diagnosis in Equivocal MRI: a Multi-center Randomised Controlled Trial

TypeinterventionalSponsorChinese University of Hong KongRan2026 to 2028Enrolled250ConditionsProstate CancerArmsMRI+PSMA-guided approach, MRI-guided approach
NCT07788625 narecruitingnot on this mapstarted 2026, after this paper: background citation

Seeing the Unseen: ¹⁸F-PSMA-1007 PET-CT-Directed Focal Therapy for MRI-Invisible Prostate Cancer (The FOCUS-PSMA Study)

TypeinterventionalSponsorThe University of Hong KongRan2026 to 2029Enrolled60ConditionsProstate CancerArmsFocal Therapy for Prostate Cancer
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Efficacy of [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Pooled it
  2. Quantitative characterization ofMolecular imaging and radionuclide therapy · 2026
    Article
  3. A comparative assessment of radiochemical purity and yield of [EJNMMI radiopharmacy and chemistry · 2026
    Article
  4. Article
  5. Review
  6. [Cancers · 2025
    Article
  7. Review
  8. Article
  9. To see clear is not enough; it is the action that counts.Translational andrology and urology · 2024
    Article
  10. Direct Patlak Reconstruction of [International journal of molecular sciences · 2023
    Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Manuela A HoffmannDepartment of Occupational Health & Safety, Federal Ministry of Defense, 53123 Bonn, Germany.
Jonas Müller-HübenthalPractice of Radiology and Nuclear Medicine, Praxis im KölnTriangle, 50679 Cologne, Germany.
Florian RosarDepartment of Nuclear Medicine, Saarland University Medical Center, 66421 Homburg, Germany.ORCID 0000-0002-2985-4099
Nicolas FischerClinic of Urology, Medical Center of Leverkusen, 51375 Leverkusen, Germany.ORCID 0000-0003-3113-6886
Finn Edler von EybenCenter for Tobacco Control Research, DK-5230 Odense, Denmark.
Hans-Georg BuchholzClinic of Nuclear Medicine, Johannes Gutenberg-University, 55101 Mainz, Germany.
Helmut J WielerMedical Center, University of Dusseldorf, 40225 Dusseldorf, Germany.
Mathias SchreckenbergerClinic of Nuclear Medicine, Johannes Gutenberg-University, 55101 Mainz, Germany.
Johannes Gutenberg University Mainz · DEFederal Ministry of Defence · DEHeinrich Heine University Düsseldorf · DEKlinikum Leverkusen · DESaarland University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHybrid imaging with prostate-specific membrane antigen (PSMA) is gaining importance as an increasingly meaningful tool for prostate cancer (PC) diagnostics and as a guide for therapy decisions. This study aims to investigate and compare the performance of [

methodsThe data of 88 biopsy-proven patients were retrospectively evaluated. PSMA-avid lesions were compared with the histopathologic Gleason Score (GS) for prostate biopsies, and the results were plotted by receiver operating characteristic (ROC)-curve. Optimal maximum standardized uptake value (SUV

results

conclusionsBoth methods demonstrated a high concordance of detected PSMA-avid lesions with histopathologically proven PC.

Indexed as

[18F]PSMA-1007[68Ga]Ga-PSMA-11prostate carcinomaPSMA hybrid imagingstaging of primary prostate cancerSUVmax cut-off level

Identifiers

PMID36078994
PMCPMC9457380
OpenAlexW4293758533

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.