ReviewJournal of clinical medicine2022
Predictive Factors for Anastomotic Leakage after Laparoscopic and Open Total Gastrectomy: A Systematic Review.
Review in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Comparative Outcomes of Spleen Preservation and Splenectomy in Total Gastrectomy for Proximal Gastric Cancer: A Systematic Review and Meta-Analysis.Journal of gastrointestinal cancer · 2025Pooled it
- Unraveling the risks: A systematic review of factors leading to esophagojejunal dehiscence after gastric cancer surgery.Surgery open science · 2026Review
- Perioperative selective decontamination of the digestive tract does not improve postoperative infectious complications after gastrectomy: a propensity score-matched analysis.Langenbeck's archives of surgery · 2026Article
- Posterior nasal hemorrhage mimicking intra-abdominal hemorrhage after gastrectomy: a case report.Frontiers in surgery · 2026Article
- Association between Candida esophagitis and esophagojejunal leakage following total gastrectomy: a retrospective cohort study.Langenbeck's archives of surgery · 2025Article
- Management of Leakage After Sleeve Gastrectomy: Outcome, Treatment Algorithm, and Predictors of Resolution.Cureus · 2025Article
- Predicting Anastomosis or Stump Leakage After Laparoscopic Gastrectomy: A Deep Learning Approach to Intraoperative Image Analysis.Journal of gastric cancer · 2025Article
- Development and validation of a LASSO-based nomogram for predicting anastomotic leakage in elderly patients after laparoscopic gastrectomy.Journal of gastrointestinal oncology · 2025Article
- Current Approaches to the Management of Postoperative Fistulas in Gastric Cancer Surgery: Experience of a Tertiary Center.Journal of clinical medicine · 2025Article
- Total Gastrectomy for Gastric Malignancy: Trends Over 15 Years in Major Morbidity, Mortality, and Patient Selection From The National Surgical Quality Improvement Program.Journal of surgical oncology · 2025Article
- [Endoscopic Treatments in Perforation or Fistula in Upper Gastrointestinal Tract].The Korean journal of helicobacter and upper gastrointestinal research · 2024Review
- Risk factors of esophagojejunal anastomotic leakage after total gastrectomy for gastric and Siewert type II/III esophagogastric cancer: a retrospective analysis from a tertiary hospital.Frontiers in oncology · 2024Article
- Treatment and Prevention of Postoperative Leakage after Gastrectomy for Gastric Cancer.Journal of clinical medicine · 2023Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this systematic review is to identify patient-related, perioperative and technical risk factors for esophago-jejunal anastomotic leakage (EJAL) in patients undergoing total gastrectomy for gastric cancer (GC). A comprehensive literature search of PubMed/MEDLINE, Embase and Scopus databases was performed. Studies providing factors predictive of EJAL by uni- and multivariate analysis or an estimate of association between EJAL and related risk factors were included. All studies were assessed for methodological quality, and a narrative synthesis of the results was performed. A total of 16 studies were included in the systematic review, with a total of 42,489 patients who underwent gastrectomy with esophago-jejunal anastomosis. Age, BMI, impaired respiratory function, prognostic nutritional index (PNI), alcohol consumption, chronic renal failure, diabetes and mixed-type histology were identified as patient-related risk factors for EJAL at multivariate analysis. Likewise, among operative factors, laparoscopic approach, anastomosis type, additional organ resection, blood loss, intraoperative time and surgeon experience were found to be predictive factors for the development of EJAL. In clinical setting, we are able to identify several risk factors for EJAL. This can improve the recognition of higher-risk patients and their outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.